PMPC-PDPA polymersomes for intra-tumoral immunotherapy

用于肿瘤内免疫治疗的 PMPC-PDPA 聚合物囊泡

• 批准号: 2094069
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2094069
• 关键词: PMPC; PDPA; polymersomes; intra; tumoral

We are evaluating the possibility to create new formulations of nanomaterials that target tumour associated immune cells and trigger a immunological response to treat both local and remotely tumour cells. We are thus preparing new formulation of tumour associated antigens with PMPC-PDPA polymersomes and along side developing new phenotypic nanomedicines to target immune-check point process to both instil an antumoral immune response and at the same time stops the tumour ability to inhibit the immune system. The student will be developing new materials; the synthesis and preparation of novel antigen loaded polymersome as well as multivalent and multiplex nanomedicine. This is well within the theme Healthcare technologies and particularly the sub-theme Developing Future Therapies: Supporting the development of novel therapies with technologies to enhance efficacy, minimise costs and reduce risk to patients.We also will be using concepts from area typical under the EPS areas of Chemical Biology and Biological Chemistry, Polymeric Materials, Soft Matter and Biological Physics as well as Biomateirals and Tissue Engineering

我们正在评估创造新的纳米材料配方的可能性，这些纳米材料针对肿瘤相关免疫细胞，并触发免疫反应来治疗本地和远程肿瘤细胞。因此，我们正在用PMPC-PDPA多聚体制备肿瘤相关抗原的新配方，同时开发新的表型纳米药物，以靶向免疫检查点过程，既注入抗肿瘤免疫反应，同时阻止肿瘤抑制免疫系统的能力。学生将开发新材料；新型抗原负载聚合物的合成和制备以及多价和多重纳米药物。这完全符合卫生保健技术的主题，特别是副主题发展未来疗法：通过提高疗效、最大限度地降低成本和降低患者风险的技术支持新疗法的开发。我们还将使用EPS领域下典型领域的概念，如化学生物学和生物化学、聚合物材料、软物质和生物物理以及生物医学和组织工程