Yeast Chromosome Structure, Replication and Segregation

该提案要求部分支持美国实验生物学联合会(FASE B)关于酵母染色体结构、复制和分离的夏季研究会议。这次会议将于2002年6月28日至7月3日在科罗拉多州的斯诺马斯举行，这是非常成功的芽殖酵母和分裂酵母染色体研究两年一次系列会议的第七次会议。酵母染色体动力学的研究对人类生物学有着重要的影响，在癌症、细胞衰老和由于染色体传递缺陷而导致的非整倍体等领域具有医学意义。因此，这一快速变化的研究领域需要专门的会议来有效地传播信息。自1990年以来，FASEB主办的会议一直是这一领域最重要的新实验发现的交流中心。2002年的会议计划将包括九个科学会议、一个主旨演讲、一个研讨会和两个海报会议。科学会议将涉及核结构和染色质重塑、端粒和端粒酶、DNA复制、细胞周期转换和DNA复制的控制、检查点、减数分裂、有丝分裂的进出、着丝粒和动粒，以及有丝分裂马达和纺锤体的动力学。为期一下午的研讨会的焦点将是酵母功能基因组学，这是一个越来越感兴趣的话题，因为它对遗传分析有巨大的潜在影响。十位杰出的科学家将作为九次全体会议和研讨会的届会主席参加这次会议。帝国癌症研究基金会主任保罗·诺尔斯将发表主题演讲。经与各届会议主席协商，我们拟定了一份99名潜在发言者的名单，我们将从中选出大约66名。大多数发言者将在2001年7月和8月被邀请，而我们计划在会议前从提交的摘要中选择其他发言者。未被选为平台演讲的参与者将被强烈鼓励展示海报。会议将限制为200名科学家，他们将根据他们的兴趣和专长进行选择，特别努力增加女性、少数民族和初级科学家的参与。我们这次会议的目标是继续保持过去六次会议所特有的极高水平的兴奋和卓越的科学水平。

This proposal requests partial support for a Federation of American Societies of Experimental Biology (FASEB) summer research conference on Yeast Chromosome Structure, Replication, and Segregation. This meeting will be held June 28 - July 3, 2002 at Snowmass, Colorado, as the seventh meeting in an extremely successful biennial series on chromosome research in budding and fission yeast. Research on yeast chromosome dynamics has a substantial impact on human biology, with medical implications in the areas of cancer, cellular aging, and aneuploidy due to chromosome transmission defects. Therefore, this rapidly moving research area requires a dedicated meeting to efficiently disseminate information. Since 1990, the FASEB-sponsored meeting has been the most important clearinghouse for new experimental findings in this field. The 2002 conference program will consist of nine scientific sessions, a keynote address, a workshop, and two poster sessions. The scientific sessions will cover nuclear architecture and chromatin remodeling, telomeres and telomerases, DNA replication, cell cycle transitions and control of DNA replication, checkpoints, meiosis, mitotic entry and exit, centromeres and kinetochores, and mitotic motors and spindle dynamics.. The focus of the afternoon-long workshop will be yeast functional genomics, a topic of increasing interest due to the tremendous potential impact on genetic analysis. Ten distinguished scientists will participate in this conference as session chairs of the nine plenary sessions and the workshop. Paul Nurse, Director of the Imperial Cancer Research Fund, will be giving the keynote address. In consultation with the session chairs, we have generated a list of 99 potential speakers from which we will make a final selection of approximately 66. Most speakers will be invited in July and August, 2001, while we plan to choose others from among the submitted abstracts prior to the meeting. Participants whose abstracts were not selected for platform talks will be strongly encouraged to present posters. The conference will be limited to 200 scientists who will be chosen on the basis of their interests and expertise, with special efforts to increase the participation of female, minority, and junior scientists. Our objective for this meeting is to continue the extremely high level of excitement and scientific excellence that has characterized the past six conferences.