Conference on Rethinking the Pathogenesis of Asthma

重新思考哮喘发病机制会议

• 批准号: 6434712
• 负责人: Jeffrey Mark Drazen
• 金额: $ 2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6434712
• 关键词: asthma; meeting /conference /symposium; pathologic process; travel

DESCRIPTION (provided by applicant): Asthma is a major cause of illness and disability worldwide. During the past 2-3 decades, the prevalence of asthma and morbidity due to asthma have increased substantially. However, these trends remain unexplained by current models of asthma pathogenesis. The goal of this conference is to bring together established and junior investigators, postdoctoral fellows and students from basic science, industrial and clinical backgrounds, representing a wide range of scientific disciplines, to actively discuss progress in the field and to reexamine the pathogenesis of asthma from the perspective of new insights into human immune system development and biology and an expanding awareness of the role of environmental factors. Examples include advances in gene discovery and receptor-mediated signaling, an appreciation of the importance of early life events in molding the allergic diathesis, and an understanding of the role of the innate immune system in the establishment and maintenance of airway inflammation and hyperreactivity. This conference will highlight current research and future directions in areas that hold promise for the development of new therapeutic agents and preventive approaches.

描述（由申请人提供）：哮喘是疾病的主要原因， 全世界的残疾人。在过去的20 - 30年里，哮喘的患病率 和哮喘的发病率显著增加。但这些 目前的哮喘发病机制模型仍然无法解释这种趋势。目标 这次会议的目的是将资深和初级研究人员聚集在一起， 来自基础科学、工业和临床的博士后研究员和学生 背景，代表广泛的科学学科，积极 讨论该领域的进展，并重新审视哮喘的发病机制， 对人类免疫系统发展的新见解的观点， 生物学和不断扩大的环境因素的作用的认识。 例子包括基因发现和受体介导的信号传导的进展， 对早期生活事件在塑造过敏性疾病中的重要性的认识 素质，并了解先天免疫系统在免疫系统中的作用。 建立和维持气道炎症和高反应性。这 会议将突出当前的研究和未来的方向， 为开发新的治疗剂和预防剂提供了希望 接近。