Development electro-mechanical model of the human heart for the study of heart failure.

开发用于研究心力衰竭的人体心脏机电模型。

• 批准号: 2096651
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2096651
• 关键词: Development; electro; mechanical; model; human

Cardiac arrhythmia are the most comment cardiac disease causing morbidity and mortality. They are characterised by irregular electrical excitation waves propagating in the heart, which impair cardiac mechanical contraction of the tissue, leading to failure of blood circulation. However, it is incompletely understood yet the mechanism underling arrhythmogenesis and/or the electrical-mechanical uncoupling in the heart failure condition. In this project, we aim to develop a novel computer model of the heart by integrating cardiac imaging, electrophysiology and biomechanics into an integral computational platform. The developed model will be used to investigate the electromechanics of the heart in the setting of heart failure condition. The output of which will increase our understanding the pro-arrhythmic effects of heart failure, which has some important clinical relevance.

心律失常是引起发病率和死亡率最高的心脏病。它们的特征在于在心脏中传播的不规则电激励波，这损害组织的心脏机械收缩，导致血液循环衰竭。然而，它是不完全理解的，但在心力衰竭条件下的心肌发生和/或电-机械解偶联的机制。在这个项目中，我们的目标是开发一个新的计算机模型的心脏，整合心脏成像，电生理学和生物力学到一个完整的计算平台。所开发的模型将用于研究心力衰竭条件下心脏的电动力学。其输出将增加我们对心力衰竭的促代谢作用的理解，这具有一些重要的临床意义。