Development electro-mechanical model of the human heart for the study of heart failure.
开发用于研究心力衰竭的人体心脏机电模型。
基本信息
- 批准号:2096651
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cardiac arrhythmia are the most comment cardiac disease causing morbidity and mortality. They are characterised by irregular electrical excitation waves propagating in the heart, which impair cardiac mechanical contraction of the tissue, leading to failure of blood circulation. However, it is incompletely understood yet the mechanism underling arrhythmogenesis and/or the electrical-mechanical uncoupling in the heart failure condition. In this project, we aim to develop a novel computer model of the heart by integrating cardiac imaging, electrophysiology and biomechanics into an integral computational platform. The developed model will be used to investigate the electromechanics of the heart in the setting of heart failure condition. The output of which will increase our understanding the pro-arrhythmic effects of heart failure, which has some important clinical relevance.
心律失常是引起发病率和死亡率最高的心脏病。它们的特点是不规则的电激发波在心脏中传播,损害心脏组织的机械收缩,导致血液循环衰竭。然而,在心力衰竭的情况下,心律失常和/或电-机械解耦的机制尚不完全清楚。在这个项目中,我们的目标是通过将心脏成像,电生理学和生物力学集成到一个完整的计算平台中来开发一个新的心脏计算机模型。所建立的模型将用于研究心力衰竭情况下心脏的电力学。它的输出将增加我们对心力衰竭的促心律失常效应的理解,这有一些重要的临床意义。
项目成果
期刊论文数量(0)
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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