Gene Mapping Technology and Bioinformatics

基因图谱技术与生物信息学

• 批准号: 6104653
• 负责人: SCOTT R DIEHL
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6104653
• 关键词: alleles; computer assisted sequence analysis; computer system design /evaluation; genetic mapping; genetic markers; genotype; human data; human genetic material tag; information system analysis; robotics

Gene mapping studies using DNA markers to detect craniofacial and oral diseases utilize a wide variety of statistical techniques. We are developing a scheme to better integrate these software tools. Since many of these programs were written elsewhere using a variety of computer languages and input formats, integrating them with our internal database will streamline the analysis process. We are constantly updating our suite of statistical analysis tools as the field of genetic epidemiology is under very rapid development, with improved methods and computer programs regularly being made available. Collaborations with colleagues at the NIAAA and Queensland Institute of Medical Research have provided us with access to unpublished software programs for genetic analyses. We have recently made available portions of our statistical analysis software to colleagues at the NHGRI and have provided training for their staff in the use of these programs. Additional efforts have been focused on incorporating our new instruments into gene mapping analyses including DNA sequencers and a robotic laboratory workstation.

利用DNA标记进行基因定位研究， 颅面和口腔疾病利用各种统计学 技术.我们正在制定一项计划，以更好地整合这些 软件工具。因为很多程序都是 在其他地方使用各种计算机语言和输入格式， 将它们与我们的内部数据库相结合， 分析过程。我们不断更新我们的统计套件， 分析工具，因为遗传流行病学领域是根据非常 快速发展，改进方法和计算机程序 定期提供。与同事合作， NIAAA和昆士兰州医学研究所 为我们提供了未发布的软件程序， 基因分析我们最近提供了我们的部分 统计分析软件的同事在NHGRI和有 为他们的工作人员提供使用这些方案的培训。 更多的努力集中在纳入我们的新的 包括DNA测序仪在内的基因图谱分析仪器 和一个机器人实验室工作站