Structure and function of membrane transporters in Mycobacterium bovis - the causative agent of bovine tuberculosis

牛结核病病原体牛分枝杆菌膜转运蛋白的结构和功能

• 批准号: 2097363
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2097363
• 关键词: Structure; function; membrane; transporters; Mycobacterium

Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a disease of cattle and is an important animal health problem both in the UK, and globally. It is estimated that the worldwide losses to agriculture due to bovine TB are predicted to be $3 billion per annum. As well as the effect on animal health bTB is a zoonotic pathogen that can cause tuberculosis (TB) in humans.This project will use high-resolution structural determination in combination with a variety of biophysical techniques to determine the molecular detail of the mechanism by which M. bovis is able to uptake nutrients. This project will open up novel targets for therapeutics and/or diagnostics and control bTB/TB disease.

牛结核（bTB）由牛分枝杆菌引起，是牛的一种疾病，是英国和全球重要的动物健康问题。据估计，全世界因牛结核病造成的农业损失预计为每年30亿美元。除了对动物健康造成影响外，bTB还是一种人畜共患病原体，可引起人类结核病。该项目将使用高分辨率结构测定与各种生物物理技术相结合，以确定牛分枝杆菌能够吸收营养的机制的分子细节。该项目将为治疗和/或诊断和控制结核/结核病开辟新的靶点。