KGF signaling in type II epithelial cells

描述（由申请人提供）：已发现KGF（角质细胞生长因子）在体外诱导肺泡II型细胞的增殖和分化。 此外，KGF在几种肺损伤模型（包括博来霉素、放射和过氧化氢）中预防肺损伤。 然而，KGF介导这些作用的机制尚不清楚。 我们的假设是，KGF介导的，至少在一定程度上通过诱导II型细胞分化的PI3激酶信号级联的远端效应，这些行动。 我们将在原代培养中研究大鼠肺泡II型细胞的信号转导途径。 了解这些信号机制将为肺损伤的治疗提供潜在的靶点。

DESCRIPTION (provided by applicant): KGF (Keratinocyte Growth factor) has been found to induce proliferation and differentiation of alveolar type II cells in vitro. In addition, KGF prevents lung injury when given prophylatically in several models of lung injury including bleomycin, radiation, and hydrogen peroxide. However, the mechanisms whereby KGF mediates these effects are unknown. Our hypothesis is that KGF mediates, at least in part these actions by inducing type II cell differentiation using distal effectors of the PI3Kinase signaling cascade. We will study signal transduction pathways of rat alveolar type II cells in primary cultures. Understanding these signaling mechanisms would provide potential targets for the treatment of lung injury.