Development of Gel Dosimeters for Radiotherapy

放射治疗用凝胶剂量计的开发

• 批准号: 6548895
• 负责人: JOHN A ADAMOVICS
• 金额: $ 10.47万
• 依托单位: HEURIS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6548895
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; computer assisted patient care; electronic recording system; mathematical model; mathematics; patient care planning; radiation therapy dosage; spectrometry

DESCRIPTION (provided by applicant): The long-term objective of this project is to develop a three-dimensional dosimeter for verifying complex conformal radiotherapeutic treatment. The overall criteria is that the dosimeter formulation must be as sensitive as but more stable than the currently available dosimeter, BANG-3 from MGS. An extensive screening study of radiolytically oxidizable and reducible compounds in aqueous gels and nonaqueous polymers was performed. From these studies we have identified several formulations that should meet the criteria of being equivalent to and more stable than the BANG-3 dosimeter. Based on these preliminary results our experimental plan calls for additional diffusion studies using a micro beam tomographic optical scanner. In addition, the color intensity versus absorbed dose, effect of concentration on G value, dependence of photon energy and dose rate, and signal stability will all be measured using a spectrophotometer at 632 nm. If the above criteria are met a full scale dosimeter will be irradiated and evaluated on a tomographic optical scanning system. PROPOSED COMMERCIAL APPLICATION: There is a need to develop a sensitive and stable 3-D radiation dosimeter to verify complex radiotherapeutic treatment plans, particularl, for the newer treatment plans such as IMRT. Even though it is difficult to predict the annual number of conformal radiotherapies performed it is clearly growing in number. There are over 600,000 patients annually requiring radiation therapy in USA.

描述（由申请人提供）：本项目的长期目标是开发一种用于验证复杂适形放射治疗的三维剂量计。总体标准是剂量计配方必须与目前可用的剂量计（来自MGS的BANG-3）一样灵敏，但更稳定。对水凝胶和非水聚合物中的放射性可氧化和可还原化合物进行了广泛的筛选研究。从这些研究中，我们已经确定了几种配方，这些配方应符合与BANG-3剂量计等效且比BANG-3剂量计更稳定的标准。基于这些初步结果，我们的实验计划要求使用微束断层光学扫描仪进行额外的扩散研究。此外，将使用分光光度计在632 nm处测量颜色强度与吸收剂量、浓度对G值的影响、光子能量和剂量率的依赖性以及信号稳定性。如果符合上述标准，将在断层光学扫描系统上对全尺寸剂量计进行辐照和评价。 拟定商业应用： 有必要开发一种灵敏和稳定的三维辐射剂量计，以验证复杂的放射治疗计划，特别是对于较新的治疗计划，如IMRT。尽管很难预测每年进行的适形放射治疗的数量，但数量显然在增长。在美国，每年有超过60万患者需要放射治疗。