Non-Invasive Intraocular Pressure Measurement Device

描述（由申请人提供）：青光眼是导致失明的主要原因 在美国，占全球失明人数的15%。的 国家眼科研究所的视力研究计划确定了 生物机制负责青光眼作为国家优先事项。最近 研究表明，许多形式的青光眼具有遗传成分。 开发一种非侵入性、准确和可靠的方法来测量LOP IN 啮齿类动物将极大地促进IOP相关基因的鉴定 视网膜和视神经的调节和敏感性， 昏迷性损伤。一种测量小鼠LOP的非侵入性技术将 能够在一只眼睛上重复测量， 研究年龄、药物和其他因素随时间对IOP的影响。 卢娜创新公司，沿着在杰克逊实验室的西蒙·约翰博士， 凯西眼科研究所的莫里森和马约诊所的杰伊·麦克拉伦博士， 建议开发一种无创眼压测量系统 在啮齿类动物中，通过提供接触面积的同时测量， 力第一阶段计划将重点开发原型眼压计， 在进行小鼠研究之前， 第二阶段计划。

DESCRIPTION (provided by applicant): Glaucoma is a leading cause of blindness in the United States and accounts for 15 percent of blindness worldwide. The Vision Research Plan for the National Eye Institute establishes identifying the biological mechanisms responsible for glaucoma as a national priority. Recent research indicates that many forms of glaucoma have a genetic component. Development of a non-invasive, accurate, and reliable method to measure lop in rodents will greatly facilitate the identification of genes involved in IOP regulation and the susceptibility of the retina and the optic nerve to glaucomatous damage. A non-invasive technique for measuring lop in mice will enable repeated measurements on a single eye and be more useful for investigating the effect of age, drugs, and other factors on IOP over time. Luna Innovations, along with Dr. Simon John at the Jackson Laboratory, Dr. John Morrison at the Casey Eye Institute, and Dr. Jay McLaren at the Mayo Clinic, propose to develop a system for non-invasive intraocular pressure measurement in rodents by providing simultaneous measurement of contact area and applied force. The Phase I program will focus on developing prototype tonometers and demonstrating feasibility with rats before advancing to mouse studies during the Phase II program.