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Dietary supplementation with glucan enhances immune fn

膳食补充葡聚糖可增强免疫功能

基本信息

批准号：
6534558
负责人：
David L. Williams
金额：
$ 15.56万
依托单位：
EAST TENNESSEE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-10 至 2004-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (APPLICANT'S ABSTRACT): Glucans are natural product polymers of glucose, which are produced by fungi, certain bacteria and plants. Glucans have demonstrated the ability to stimulate immunity and increase resistance to infectious challenge following systemic administration, i.e., N, IP, IM or SQ. As natural products, glucans are found as fiber in the normal diet. Additionally, glucans have been identified as components of Chinese, Japanese and Indian traditional medicines. Recently, several dietary supplements have appeared on the market which are reported to contain glucan. The manufacturers have inferred from the scientific literature that dietary supplementation with glucans will have beneficial effects comparable to those observed with systemic administration. The development of a dietary supplement which could increase immunocompetence and enhance resistance to common infections would be of significant benefit to human health. However, the evidence that dietary supplementation with glucans will enhance immunity is limited and controversial and there is no evidence that these supplements will increase resistance to common infectious diseases. The objectives of this R21 exploratory research program are to determine whether dietary supplementationwith glucan will modulate immune function and, more importantly, whether oral glucans will increase resistance to common infectious diseases. There are two specific aims. First, we will characterize the local and systemic immunomodulation associated with dietary supplementation of glucan. Second, we will determine whether oral administration of (1--3)-(3-D-glucans will enhance resistance to challenge with the respiratory pathogens, Streptococcus neumoniae or murine adapted influenza A/PR8/34 HIM virus. At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases.

性状（申请人摘要）：葡聚糖是天然产物聚合物，葡萄糖，由真菌，某些细菌和植物产生。葡聚糖具有证明了刺激免疫力和增加抵抗力的能力，全身给药后的感染性激发，即，N、IP、IM或SQ。作为天然产物，葡聚糖在正常饮食中以纤维形式存在。此外，葡聚糖已被确定为中国、日本和美国的成分。印度传统医药。最近，几种膳食补充剂市场上出现的含有葡聚糖的产品。制造商从科学文献中推断，葡聚糖将具有与全身性局开发一种膳食补充剂，免疫活性和增强对常见感染的抵抗力将是对人体健康有重大益处。然而，有证据表明，饮食补充葡聚糖可增强免疫力是有限且有争议的没有证据表明这些补充剂会增加抵抗力，常见传染病。R21探索性研究的目的是计划是确定饮食中添加葡聚糖是否会调节免疫功能，更重要的是，增强对常见传染病的抵抗力。有两个具体目标。首先，我们将描述局部和全身免疫调节相关的饮食中补充葡聚糖。第二，我们将确定是否口头施用（1- 3）-（3-D-葡聚糖将增强对呼吸道病原体，链球菌或鼠适应性流感 A/PR 8/34 HIM病毒。在这项研究的成功结束时，确定饮食中补充葡聚糖对调节免疫能力以及口服葡聚糖是否会增加抵抗力传染性疾病。