Dietary supplementation with glucan enhances immune fn

说明(申请人摘要)：葡聚糖是一种天然产物聚合物 葡萄糖，由真菌、某些细菌和植物产生。葡聚糖有 表现出激发免疫力和增强抵抗力的能力 系统性给药后的传染性挑战，即N、IP、IM或SQ。 作为天然产物，葡聚糖在正常饮食中以纤维的形式存在。 此外，葡聚糖已被鉴定为中国、日本 和印度的传统药物。最近，几种膳食补充剂已经 出现在市场上，据报道含有葡聚糖。制造商 从科学文献中推断，饮食补充剂与 葡聚糖的有益效果将与全身用药观察到的效果相当 行政管理。一种膳食补充剂的开发可以增加 增强对常见感染的免疫能力和抵抗力将是 对人类健康大有裨益。然而，有证据表明饮食 补充葡聚糖将增强免疫力有限且有争议 没有证据表明这些补充剂会增加对 常见传染病。这项R21探索性研究的目标 计划是确定饮食补充剂中添加葡聚糖是否会 调节免疫功能，更重要的是，口服葡聚糖是否会 增强对常见传染病的抵抗力。有两个具体目标。 首先，我们将描述与局部和全身免疫调节相关的 在饮食中补充葡聚糖。第二，我们将确定是否口头 给予(1-3)-(3-D-葡聚糖)将增强对 呼吸道病原体，肺炎链球菌或小鼠适应流感 A/PR8/34HIM病毒。在这项研究成功结束时，我们将拥有 确定了添加葡聚糖的饮食补充剂对 调节免疫活性和口服葡聚糖是否会增加抵抗力 到传染病。

DESCRIPTION (APPLICANT'S ABSTRACT): Glucans are natural product polymers of glucose, which are produced by fungi, certain bacteria and plants. Glucans have demonstrated the ability to stimulate immunity and increase resistance to infectious challenge following systemic administration, i.e., N, IP, IM or SQ. As natural products, glucans are found as fiber in the normal diet. Additionally, glucans have been identified as components of Chinese, Japanese and Indian traditional medicines. Recently, several dietary supplements have appeared on the market which are reported to contain glucan. The manufacturers have inferred from the scientific literature that dietary supplementation with glucans will have beneficial effects comparable to those observed with systemic administration. The development of a dietary supplement which could increase immunocompetence and enhance resistance to common infections would be of significant benefit to human health. However, the evidence that dietary supplementation with glucans will enhance immunity is limited and controversial and there is no evidence that these supplements will increase resistance to common infectious diseases. The objectives of this R21 exploratory research program are to determine whether dietary supplementationwith glucan will modulate immune function and, more importantly, whether oral glucans will increase resistance to common infectious diseases. There are two specific aims. First, we will characterize the local and systemic immunomodulation associated with dietary supplementation of glucan. Second, we will determine whether oral administration of (1--3)-(3-D-glucans will enhance resistance to challenge with the respiratory pathogens, Streptococcus neumoniae or murine adapted influenza A/PR8/34 HIM virus. At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases.