CORE--LABORATORY SERVICES

核心——实验室服务

• 批准号: 6611079
• 负责人: KARL HERRUP
• 金额: $ 20.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6611079
• 关键词: Alzheimer's disease; animal colony; biomedical facility; disease /disorder model; genetically modified animals; laboratory mouse; neurogenetics

During the past ten years, the scope of Alzheimer's disease research has expanded dramatically. This growth has been due in large part to the development of new basic research tools that have enable a much wider range of laboratory experiments to be performed. The mission of our ADRC Core facilities is to provide high quality resources to a broad range of Alzheimer's researchers, and through this activity to encourage and support Alzheimer's disease research throughout the biomedical community. The Laboratory Services has been established to meet a growing demand from our researchers for access to biological resources that are otherwise difficult for them to obtain, in particular, the animal models that are so rapidly advancing our field. To achieve this end, the following goals have been set for this Core. to maintain breeding stock for local investigators of animal models of Alzheimer's disease and related dementias. to provide a facility in which these models can be aged under pathogen-free microisolator conditions to monitor and quality assure the genotype and genetic background of the animals and to assist affiliated researchers in strategies for experiments to maintain a selection of aged wild-type animals of the most commonly used wild-type strains for use by all members of the local Alzheimer's research community. to promote the use of animal models as a tool of discovery The structure for this facility has been designed in such a way as to provide for both consistency and flexibility. The goal is service and the provision of resources that are truly needed by our local researchers. The realization of this plan should significantly improve the climate for Alzheimer's research.

在过去的十年里，阿尔茨海默病的研究范围急剧扩大。这一增长在很大程度上是由于新的基础研究工具的发展，使更广泛的实验室实验得以进行。我们ADRC核心设施的使命是为范围广泛的阿尔茨海默病研究人员提供高质量的资源，并通过这一活动鼓励和支持整个生物医学界的阿尔茨海默病研究。实验室服务的建立是为了满足我们的研究人员对获取生物资源的日益增长的需求，否则他们很难获得这些资源，特别是正在如此迅速地推进我们的领域的动物模型。为了实现这一目标，为这一核心设定了以下目标。为当地阿尔茨海默病和相关痴呆症动物模型的研究人员维持繁育种群。提供一种设施，使这些模型可以在无病原体的微型隔离器条件下老化，以监测和确保动物的基因和遗传背景，并协助附属研究人员制定实验策略，以选择最常用的野生类型老年动物，供当地阿尔茨海默氏症研究社区的所有成员使用。为了促进动物模型作为发现工具的使用，该设施的结构设计既要有一致性，又要有灵活性。我们的目标是提供当地研究人员真正需要的服务和资源。这一计划的实现应该会显著改善阿尔茨海默氏症的研究环境。