ADULTS AIDS CLINICAL TRIALS UNIT UPR ADULT ACTU

描述(摘自申请者摘要)：波多黎各大学 (普遍定期审议)ACTU单位在几个月内积累了大量患者 重要的临床试验，并建立了一个基础设施小组。在 在过去的36个月里，普遍定期审议成人行动联盟参加了18个不同的行动小组 审判。累计有231名新患者参加 研究和分研究。所有的患者都是西班牙裔，并且是分层的 如下：36%的女性，65%的男性，21.6%的注射毒品 用户(IDU)。UPR成人ACTU计划立即进行合作研究 与药房研究科合作执行第一阶段和第二阶段的药代动力学 (PK)和细胞内浓度试验，以及临床试验 天真和严重预处理的个人、妇女和注射吸毒者。他们将登上 代谢并发症的这些重要方面和新的治疗方法 免疫增强剂等。普遍定期审议行动联盟，作为行动小组的一部分， 提供了一个机会来研究流行病学和 少数民族人群艾滋病的临床表现。它还提供了许多 需要为患者提供支持性和治疗性替代方案。

DESCRIPTION (adapted from applicant's abstract): The University of Puerto Rico (UPR) ACTU Unit has accrued significant numbers of patients for several important clinical trials and has developed an infrastructure group. In the last 36 months, the UPR Adult ACTU has participated in 18 different ACTG trials. A total of 231 new patients have been accrued to participate in studies and sub-studies. All of the patients are Hispanics and are stratified as follows: 36 percent females, 65 percent males, 21.6 percent Injection Drug Users (IDU). The UPR Adult ACTU plans for immediate research in collaboration with the Pharmacy Research Section to perform Phase I and II pharmacokinetic (PK) and intracellular concentration trials, as well as clinical trials in naive and heavily pre-treated individuals, women and IDUs. They will embark in such important aspects of metabolic complications and novel approaches with immunological enhancers, among others. The UPR ACTU, as a part of the ACTG, offers an opportunity to study variation patterns in the epidemiological and clinical manifestations of AIDS in minority groups. It also provides for much needed supportive and therapeutic alternatives to patients.