GERIATRIC NOCTURIA AND NIGHTTIME INCONTINENCE

老年夜尿症和夜间尿失禁

• 批准号: 6565734
• 负责人: JOSEPH G. OUSLANDER
• 金额: $ 29.31万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6565734
• 关键词: aging; arginine vasopressin; body water; circadian rhythms; clinical research; hormone therapy; human subject; human therapy evaluation; osmotic pressure; urinalysis; urinary incontinence; urination disorder

The objectives of this study are to determine if geriatric patients with nocturnal polyuria: 1) have deficits in their ability to concentrate their urine compared to older individuals without nocturnal polyuria; and 2) have low levels of arginine vasopressin (AVP); and if so, if they respond by increasing their urine osmolality to exogenous AVP after an overnight water deprivation test.

本研究的目的是确定有夜间多尿的老年患者是否：1)与没有夜间多尿的老年人相比，他们集中尿液的能力存在缺陷；以及2)精氨酸加压素(AVP)水平较低；如果是，他们是否在夜间断水试验后通过增加尿液渗透压来应对外源性AVP。