CORE--NMR

普渡大学癌症中心的核磁共振（NMR）共享资源的目标是为癌症中心的研究人员提供必要的NMR服务。这些服务包括在九台光谱仪上提供样品分析，并为研究人员提供建立和解释NMR实验的专家协助。所要求的资金将支持在研究中使用NMR的癌症中心成员的这一基本资源。目前，至少有20名获得同行审查资金的主要调查员广泛使用该机制。利用NMR共享资源的特定癌症研究领域包括：I）检查涉及人类癌症的细胞过程。NMR用于获得有关细胞转化中涉及的蛋白质和酶的机械和结构信息。2)抗癌药物作用机制的研究。3)开发已知和新抗癌剂的合成路线。NMR是合成和药物发现计划的绝对要求，旨在增加已知抗癌化合物的供应以及设计新化合物。NMR用于监测反应过程并确定这些复杂合成分子的结构。NMR共享资源为普渡大学的癌症研究人员提供最先进的NMR设备和服务。该设施对于成功完成许多不同的癌症相关研究项目至关重要，并为了解和治疗癌症提供必要的服务。

The goal of the Nuclear Magnetic Resonance (NMR) Shared Resource at the Purdue University Cancer Center is to provide essential NMR services to Cancer Center investigators. These services include providing sample analysis on nine spectrometers and expert assistance to researchers in setting up and interpreting NMR experiments. The funds requested will support this essential resource for Cancer Center members who use NMR in their research. Currently, at least 20 principal investigators with peer reviewed funding make extensive use of the Facility. Specific cancer research areas that utilize the NMR shared resource include: I) Examination of cellular processes involved in human cancer. NMR is used to obtain mechanistic and structural information about proteins and enzymes involved in cell transformation. 2) Studies of the mechanisms of action of anticancer drugs. 3) Development of synthetic routes to known and new anti-cancer agents. NMR is an absolute requirement for the synthetic and drug discovery programs targeted to increase the supply of known anticancer compounds as well as -to devise new compounds. NMR is used to monitor the course of reactions and to determine the structure of these complex synthetic molecules. The NMR Shared Resource provides state of the art NMR equipment and services for cancer researchers at Purdue University. This Facility is critical for the successful completion of many diverse cancer-related research projects and provides a necessary service in efforts to understand and treat cancer.