CORE--BIOSENSOR/INTERACTION ANALYSIS FACILITY

生物传感器/相互作用分析核心于1997年正式成立，以满足对大分子相互作用分析日益增长的需求。最初的资金部分由癌症中心提供，通过核心赠款发展基金和非核心赠款来源，以及医学院。医学教授欧文柴肯博士担任机构主任。Chaiken博士是使用生物传感器进行动力学相互作用分析以及生物分子识别领域的国家专家。Chaiken博士的实验室是最早将生物传感技术应用于特定大分子相互作用系统的实验室之一。这项生物传感器工作源于Chaiken博士早期开发的用于使用固定化配体进行相互作用分析的分析亲和色谱法。Chaiken博士计划并建立了生物传感器/相互作用分析中心，现在担任其设施总监。该设施的技术总监。Gabriela Canziani博士在酶动力学、酶催化位点的结构-功能和分光光度法（包括荧光光谱法和脂质-蛋白质相互作用的生物物理分析）方面拥有十多年的经验。在这一启动期间，使用量稳步增加。绝大多数用户都是回头客，他们通过扩大现有项目的范围和启动新项目来增加使用量。在最近的预算年度，83%的使用是由癌症中心成员完成的，79%是由癌症中心成员通过同行评审的资金完成的。随着该核心成为NCI批准的癌症中心共享资源，并且随着更多的研究人员熟悉其不断增长的能力，癌症中心成员的使用量将在下一个项目期间增加。

The Biosensor/Interaction Analysis Core was formally established in 1997 to meet the growing need for macromolecular interaction analysis. Initial funding was partially provided by the Cancer Center, through both Core Grant Developmental Funds and non-Core Grant sources, as well as by the School of Medicine. Irwin Chaiken, PhD, Professor of Medicine, serves as Facility Director. Dr. Chaiken is a national expert in kinetic interaction analysis using biosensors as well as in the field of biomolecular recognition. Dr. Chaiken's laboratory was one of the first to apply the use of biosensory technology to specific macromolecular interaction systems. This biosensor work emerged from Dr. Chaiken's earlier work in the development of analytical affinity chromatography for interaction analysis using immobilized ligands. Dr, Chaiken planned and established the Biosensor/Interaction Analysis ore and now serves as it's Facility Director. The facility's Technical Director,. Gabriela Canziani, PhD, has more than ten years of experience in enzyme kinetics, structure-function of the catalytic sites of enzymes, and spectrophotometric methods, including fluorescence spectroscopy and biophysical analysis of lipid- protein interactions. Usage has increased steadily during this start-up period. The vast majority of users are repeat customers who are increasing their usage by both expanding the scope of current projects and initiating new projects. During the most recent budget year, 83% of usage was done by Cancer Center members and 79% was by Cancer Center members with peer- reviewed funding. Increased usage by Cancer Center members is very much anticipated for the next project period as this core becomes an NCI- approved Cancer Center Shared Resources and as more investigators become familiar with its growing capabilities.