Profiling Cytochrome P450 Enzymes Using Chemical Probes

使用化学探针分析细胞色素 P450 酶

• 批准号: 2105263
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2105263
• 关键词: Profiling; Cytochrome; P450; Enzymes; Using

CYP450s are a superfamily of enzymes responsible for phase I metabolism and biosynthesis across the tree of life. CYP450s are understudied in plants and a greater knowledge of the key players would allow for more informed design of plant protection products (herbicides, fertilisers, insecticides). The project outlined herein aims to develop a probe library for use in the studying of these enzymes. Traditional chemical synthesis methods will be employed and, following routine biological evaluation, next generation probes will be designed and synthesised throughout the project.BBSRC priority areas related to the project:Food, nutrition and healthSustainably enhancing agricultural productionGlobal food securityAfS, ENWW

CYP450 是负责生命树第一阶段代谢和生物合成的酶超家族。 CYP450 在植物中的研究不足，对关键参与者的更多了解将有助于更明智地设计植物保护产品（除草剂、肥料、杀虫剂）。本文概述的项目旨在开发用于研究这些酶的探针库。整个项目将采用传统的化学合成方法，并在常规生物学评估后设计和合成下一代探针。BBSRC 与该项目相关的优先领域：食品、营养和健康可持续提高农业生产全球粮食安全AfS，ENWW