Developing a microfluidics-based platform for rapid testing of microbial resistance to antibiotics

开发基于微流体的平台，用于快速测试微生物对抗生素的耐药性

• 批准号: 2106196
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2106196
• 关键词: Developing; microfluidics; based; platform; rapid

Microbial resistance to antibiotics (also referred to as antimicrobial resistance, or AMR) has become increasingly challenging worldwide, with substantial societal and economic impact. This may be attributed to a variety of human actions, such as unnecessary prescription in healthcare, blanket prescription in agriculture and careless release of antibiotics into the environment. Lack of appropriate and rapid testing methods is regarded as one of the main reasons for over- and inappropriate use of antibiotics. The aim of this project is to develop a microfluidics-based platform for rapid testing of microbial resistance to antibiotics. The main objectives are (i) design and fabrication of microfluidic devices, which consist of microchannels for sampling and reaction; (ii) development of a microfluidics-based bioassay for detection; (iii) integration of the microfluidic device with detection; and (iv) test and evaluation of the platform for AMR applications.

微生物对抗生素的耐药性（也称为抗菌素耐药性或AMR）在全球范围内变得越来越具有挑战性，并产生重大的社会和经济影响。这可能归因于各种人类行为，例如医疗保健中不必要的处方，农业中的一揽子处方以及不小心将抗生素释放到环境中。缺乏适当和快速的检测方法被认为是过度和不适当使用抗生素的主要原因之一。该项目的目的是开发一种基于微流体的平台，用于快速检测微生物对抗生素的耐药性。主要目标是：（i）设计和制造微流控装置，包括用于采样和反应的微通道;（ii）开发基于微流控的生物检测;（iii）微流控装置与检测的集成;以及（iv）测试和评估AMR应用平台。