NIDA CLINICAL TRIALS NETWORK: UCLA RESEARCH NODE

这并不是说药物滥用治疗没有取得任何进展--相反，问题是这些进展并没有转化为社区一级的治疗系统。这种“脱节”(Leshner)或“GAP”(医学研究所)促使人们建议NIDA建立一个机制，促进将研究成果转移到社区。建议的临床试验网络(CTN)就是这一建议的结果。按照设想，拟议的加州大学洛杉矶分校CTN节点将进行和参与药物滥用依赖的行为、药理学以及行为和药物联合治疗试验，并将对CTN节点内和跨CTN节点的治疗实践进行研究。加州大学洛杉矶分校的节点将有效地将一批优秀的调查人员和具有专业知识的各种社区治疗计划聚集在一起，以响应CTN设想的需求。该组织有组织和进行多中心研究的记录，并有与NIDA和全国各地的其他调查人员合作，以及与社区团体合作的成功历史。该提案概述了现有的临床基础设施，其中包括南加州以社区为基础的治疗诊所系统，并描述了与其他四个以社区为基础的诊所的进一步伙伴关系，每个诊所都为CTN做出了独特的贡献。该提案详细说明了拟议小组的培训和研究经验，以及可以扩大以适应该网络需要的既定培训和研究基础设施。该提案概述了该集团在过去几十年中成功使用的行政基础设施，并可以加以加强，以满足CTN的要求。最后，该提案提出了三个研究概念，供指导委员会审议。这些概念体现了该小组关于适合在CTN内研究的项目的经验和目前的想法。

It is not that substance abuse treatment has made no advances - instead, the problem is that these advances have not translated into the treatment system at the community level. This "disconnect" (Leshner) or "gap" (the Institute of Medicine) prompted the recommendation that NIDA establish a mechanism to facilitate transfer of research findings into the community. The proposed Clincial Trial Network (CTN) is the result of that recommendation. As envisioned, the proposed UCLA CTN Node will conduct and participate in behavioral, pharmacological, and combined behavioral and pharmacological treatment trials for drug abuse dependence and will conduct research on treatment practices within and across CTN Nodes. The UCLA Node would effectively bring together an outstanding group of investigators and a diverse array of community treatment programs with the expertise to respond to the envisioned needs of the CTN. The group has a track record for organizing and conducting multi-center studies and a successful history of working collaboratively with NIDA and other investigators across the nation on the one hand, and with community groups on the other. This proposal outlines an existing clinical infrastructure, which encompasses a system of community-based treatment clinics in Southern California, and describes a further partnership with four other community-based clinics, each with unique contributions for the CTN. The proposal details the training and research experience of the proposed group and the established training and research infrastructure that can be expanded to accommodate the needs of the Network. The proposal outlines an administrative infrastructure that the group has used successfully for the past several decades and which can be enhanced to meet CTN requirements. Finally, the proposal presents three research concepts for the Steering Committee's consideration. These concepts exemplify the group's experience and current thinking about projects that would be suitable for study within the CTN.