Case-Control Study of Pancreas Cancer Etiologic Factors

胰腺癌病因的病例对照研究

• 批准号: 6678257
• 负责人: Harvey A Risch
• 金额: $ 66.11万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6678257
• 关键词: Helicobacter; acidity /alkalinity; adenocarcinoma; cadmium; cancer risk; case history; clinical research; diet; disease /disorder etiology; duodenum; epidemiology; genetic polymorphism; genetic screening; genetic susceptibility; human middle age (35-64); human old age (65+); human subject; infection related neoplasm /cancer; lifestyle; nitroso compounds; nutrition related neoplasm /cancer; nutrition related tag; occupational hazard; pancreas neoplasms; serology /serodiagnosis; stomach

DESCRIPTION (provided by applicant): In the US in 2001, there were about 29,000 new cases of cancer of the pancreas, and nearly that number died from it, making it the 4th most frequent cause of cancer death, after lung, breast/prostate and colorectal cancer. Over the lifetime, more than 1% of the population is affected, with blacks having a bit higher rates than whites. Survival with this cancer is dismal: one year about 20-30%, and 5-year, about 5%. Most patients present with advanced disease, and the standard treatments do not much alter the progressive, fatal course. Aside from major-gene causes underlying perhaps 5% of cases, the one known risk factor for pancreatic cancer is cigarette smoking, which doubles the risk. Studies of dietary factors have not been entirely consistent but do suggest associations of higher risk with animal product intake and lower risk with consumption of fruits or vegetables. This application describes a new hypothesis on the etiology of pancreatic cancer, and provides a substantial body of laboratory and epidemiologic evidence in support of it. To examine this hypothesis, we will conduct, in the state of CT, a population-based case-control study to examine infectious, genetic, dietary, lifestyle and medical history factors. In total, 600 pancreas-cancer cases aged 35-79 years will be identified prospectively via the ultra-rapid program of the Rapid Case Ascertainment Shared Resource at Yale. About 600 randomly selected population controls will be frequency matched to the cases by age and gender. Controls will be identified using enhanced random-digit dialing methods. All subjects will be interviewed in person by trained interviewers using a standardized, structured questionnaire that will include sections on tobacco use and medical history, a standard food frequency/supplements questionnaire, and questions about other factors specific to our hypothesis. A small blood sample will be drawn for use in testing for exposure to certain infections, and for four DNA polymorphisms relevant to our hypothesis. Average daily intake of dietary nutrients will be calculated from the diet histories, and uni- and multivariate analyses will be used to estimate relative risks for comparison of the cases with the controls. The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project.

描述（由申请人提供）：在2001年，在美国，大约有29,000例新的胰腺癌病例，几乎这一数字死亡，这使其成为肺，乳腺/前列腺癌和结肠直肠癌后第四大常见的癌症死亡原因。在一生中，超过1％的人口受到影响，黑人的率高于白人。患有这种癌症的生存令人沮丧：一年约20-30％，5年，约5％。大多数患有晚期疾病的患者，标准治疗并没有改变进行性致命病程。除了大约5％的病例的基本原因外，胰腺癌的一个已知危险因素是吸烟，这使风险增加了一倍。对饮食因素的研究并不完全一致，但确实表明，较高的风险与动物产品摄入量相关，而较低的风险与水果或蔬菜的消费相关。该应用描述了关于胰腺癌病因的新假设，并提供了大量的实验室和流行病学证据来支持它。为了审查这一假设，我们将在CT状态下进行基于人群的病例对照研究，以检查传染性，遗传，饮食，生活方式和病史因素。总共将通过耶鲁大学快速案例发现共享资源的超强计划来确定600名胰腺癌病例。大约有600个随机选择的人群对照将符合年龄和性别案例的频率。 将使用增强的随机数字拨号方法来识别控件。所有受试者都将通过训练有素的访调员亲自采访，使用标准化的结构化问卷，其中包括有关烟草使用和病史的部分，标准食品频率/补充问卷以及有关我们假设的其他因素的问题。将抽取一个小血液样本，用于测试暴露于某些感染的情况下，以及与我们的假设相关的四个DNA多态性。饮食养分的平均每日摄入量将根据饮食史计算，并将使用单变量分析来估计将病例与对照组进行比较的相对风险。这里要检查的因素对胰腺癌几乎没有关注，拟议的研究将在剧烈，大规模和综合项目中系统地评估它们。