Exposure levels of persistent pollutants in urban anglers

城市钓鱼者持久性污染物的暴露水平

• 批准号: 6578821
• 负责人: ANNE L. GOLDEN
• 金额: $ 8.37万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578821
• 关键词: Crustacea; Mollusca; bioaccumulation; blood chemistry; chlordane; clinical research; dichlorodiphenyltrichloroethane; disease /disorder proneness /risk; environmental exposure; epidemiology; fish; food contamination; halobiphenyl /halotriphenyl compound; hazardous substances; human subject; mercury

DESCRIPTION (Taken from application) Sediments and fish from the lower Hudson River estuarine region contain the residues of decades of contamination with persistent, bioaccumulative environmental pollutants. The complex mix of chemicals found in these waters includes polychlorinated biphenyls (PCBs), mercury, and the organochlorine pesticides chlordane and DDT. Because of concern for risk of fetal neurotoxicity, advisories issued by the States of New York and New Jersey recommend that women of childbearing age abstain completely from eating fish and shellfish from this region. Despite these warnings, many recreational and subsistence fishers still regularly consume their local catch and share with family members and friends. To assess human body burdens of persistent pollutants, a pilot study of 46 local anglers was conducted in 1998-99 by investigators from the Mount Sinai Superfund Basic Research Program. It was the first investigation ever undertaken of human body burdens of persistent pollutants in persons who consume fish and shellfish from the lower Hudson River. The fish consumption practices reported by the anglers put them at high exposure risk. The data showed that consumers of locally caught fish and shellfish had higher body burdens of PCBs and organochlorine pesticide residues than non-consumers. There was a strong positive exposure-response gradient between fish and crab consumption and serum levels of highly chlorinated PCBs and DDE. A cross-sectional, biomarker-based epidemiologic study has been proposed that will extend this pilot study. To further characterize patterns of human exposure, it will measure body burdens of biologically persistent environmental pollutants in urban anglers, female members of their families with whom they share their catch, and a group of unexposed controls from the same communities. Levels of organochlorines will be measured in blood, and methylmercury will be measured in scalp hair. Body burdens will be correlated with number of years of fish and shellfish consumption, amount and species consumed, and areas where the fish or crabs were caught, and exposure-response gradients will be sought. Analyses will be performed to relate levels and relative distributions of contaminants in fish-and shellfish- eaters to patterns and sources of environmental contamination in the lower Hudson and New York-New Jersey Harbor.

描述(取自应用程序) 哈德逊河下游河口地区的沉积物和鱼类含有 几十年来持续的、生物累积的污染残留物 环境污染物。在这些水域中发现的复杂的化学混合物 包括多氯联苯、汞和有机氯 杀虫剂氯丹和滴滴涕。出于对胎儿风险的担忧 神经毒性，纽约州和新泽西州发布的公告 建议育龄妇女完全禁食鱼类 以及来自这一地区的贝类。尽管有这些警告，许多娱乐和 自给性渔民仍然定期消费当地的渔获物，并与 家人和朋友。为了评估人体的持续负荷 在1998-99年度，一项针对46名本地垂钓者的试验研究，由 西奈山超级基金基础研究项目的研究人员。确实是 有史以来第一次对持续的人体负担进行的调查 食用哈德逊河下游鱼类和贝类人群的污染物 河。垂钓者报告的鱼类消费习惯使他们处于 高暴露风险。数据显示，当地捕捞的鱼和 贝壳类海产体内的多氯联苯和有机氯农药含量较高。 残留量高于非消费者。有很强的阳性暴露反应 鱼和蟹的摄入量与血清高密度脂蛋白水平之间的梯度 氯化多氯联苯和滴滴涕。一种基于生物标记物的横断面流行病学 已经提出了一项研究，将扩大这一试点研究。为了进一步 表征人类暴露的模式，它将测量身体负担 城市垂钓者中的生物持久性环境污染物，女性 与其分享捕获物的家庭成员，以及一群 来自相同社区的未暴露的对照。有机氯的水平将 在血液中检测到甲基汞，在头皮头发中也检测到甲基汞。身躯 负担将与养鱼和贝类的年限相关。 消耗量、消耗量和种类，以及鱼或蟹的区域 被发现，并将寻求暴露-反应梯度。分析将是 对鱼类中污染物的水平和相对分布进行关联-和 食贝动物对环境污染的模式和来源 在哈德逊河下游和纽约-新泽西港。