CORE--TRACE METAL ANALYSIS

核心--痕量金属分析

• 批准号: 6577233
• 负责人: C Page Chamberlain
• 金额: $ 16.33万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577233
• 关键词: analytical chemistry; biomedical facility; environmental toxicology; hazardous substances; heavy metals; mass spectrometry

The Trace Metal Analysis Core is a shared resource for state-of-the-art trace and ultratrace analyses of both metals and their species. The central feature of the core is a magnetic sector High Resolution Inductively Coupled Plasma Mass Spectrometer (HR-ICPMS) which provides unsurpassed detection limits, interference free accurate analyses while allowing high sample throughput. Additionally, ICPMS is capable of precise isotype ratio dilution analyses for elements with more than one stable isotope, tracer experiments as well as highly accurate isotope dilution analyses for elements with more than one stable isotope. Combined with chromatographic techniques, HR-ICPMS represents the most sensitive element-specific detection technique for different metal species. Method developments during the first four years of the SBRP program at Dartmouth College provided highly sophisticated and cost- effective analytical procedures for a variety of different elements and their species in a number of systems. Further developments can be provided in the future given new research objectives.

痕量金属分析核心是一种共享资源，用于对金属及其种类进行最先进的痕量和超痕量分析。核心的核心特征是扇形磁高分辨率电感耦合等离子体质谱仪 (HR-ICPMS)，它提供无与伦比的检测限、无干扰的精确分析，同时允许高样品通量。此外，ICPMS 能够对具有一种以上稳定同位素的元素进行精确的同位素比率稀释分析、示踪实验以及对具有一种以上稳定同位素的元素进行高精度同位素稀释分析。与色谱技术相结合，HR-ICPMS 代表了针对不同金属种类的最灵敏的元素特异性检测技术。达特茅斯学院 SBRP 项目前四年的方法开发为许多系统中的各种不同元素及其种类提供了高度复杂且具有成本效益的分析程序。鉴于新的研究目标，未来可以提供进一步的发展。