Factors that influence the avian T and B cell repertoire

适应性免疫系统的T和B细胞具有显著的多样性，每个独特的克隆都能够对特定的抗原做出反应。考虑到这一点，高通量测序(HTS)技术为在健康和疾病背景下检查T和B细胞谱系开辟了新的途径。然而，这项技术尚未被应用于分析鸟类的适应性免疫谱系，尽管它们对粮食安全或动物健康等全球问题很重要。本项目的目的是应用一种基于HTS的方法来研究禽类宿主获得性免疫库的各种驱动因素的影响。因此，微生物定植、疫苗接种和感染性挑战等因素将根据它们对T和B细胞库的影响进行评估。这项研究的结果将提供关于禽类免疫系统的有价值的信息，同时也有可能指导禽类部门当前和未来的做法。

The adaptive immune system possesses a remarkable diversity in its T and B cells, with each unique clone being able to respond to a specific antigen. With this in mind, high-throughput sequencing (HTS) technology has opened new avenues for examining the T and B cell repertoire in the context of both health and disease. However, this technology has not yet been applied to analyse the adaptive immune repertoire of birds, in spite of their importance to global issues such as food security or animal health. The aim of this project is to apply an HTS-based methodology to study the impact of various drivers of the adaptive immune repertoire of avian hosts.Therefore, factors such as microbial colonisation, vaccination, and infectious challenge will be evaluated in terms of their effects on the T and B cell repertoire. The outcomes of this research will provide valuable information about the avian immune system, while also having the potential to guide current and future practices in the poultry sector.