Calcium Foods and Bone Health of Adolescent Girls

钙食物与青春期女孩的骨骼健康

• 批准号: 6579153
• 负责人: JOAN LAPPE
• 金额: $ 17.81万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6579153
• 关键词: adolescence (12-20); body physical activity; bone density; bone development; clinical research; densitometry; developmental nutrition; diet therapy; dietary calcium; disease /disorder prevention /control; female; human subject; human therapy evaluation; longitudinal human study; nutrient intake activity; nutrition related tag; osteoporosis

DESCRIPTION (provided by applicant): Osteoporosis is a major health problem. Optimum development of the skeleton during youth is crucial in prevention of osteoporosis, a condition that fractures bone late in life because of reduced bone mass and bone quality. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone health and be less likely to develop osteoporosis in later years. Yet bone health in youth has not been adequately addressed. In this application, we propose to extend our four-year intervention study of the effects of a high calcium diet on bone quality in pubertal girls. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in adolescent females. The hypothesis to be tested is: adolescent females who consume a high calcium diet will have a greater increase in bone quality, as measured by densitometry and ultrasound, then adolescent females who consume their usual dietary calcium intake. The study uses an experimental design in which 58 participants (26 treatment and 32 control) will be followed for an additional 4.5 years for a total of 8.5 years. Participants are a convenience sample who were age 9 when enrolled. Girls in the treatment group will continue to be given high calcium foods to supply at least 1500 mg/day while girls in the control group will be asked to continue consuming their usual diet. Measurements to be made at baseline, every six months, and at the end of the study include height, weight, Tanner stage, and medical and social history. Usual physical activity and dietary intake will be determined every three months. Funding of this project in the next cycle would enable us to follow these young females continuously from age 9 to age 18.5. To our knowledge, this would be the first intervention to evaluate the effects of optimal calcium intake on bone health through out the period of highest bone mass and bone quality accrual. This enthusiastic group of adolescent participants provides us with confidence that we can successfully complete this ambitious project. Evidence of a positive effect of increased calcium intake from food sources on bone quality in adolescent females would provide strong support for educational efforts targeted at adolescent females, parents and care providers. Negative findings would provide support for further research into other methods of concomitant methods of maximizing skeletal development.

描述(申请人提供)：骨质疏松症是一个主要的健康问题。年轻时骨骼的最佳发育对于预防骨质疏松症至关重要，骨质疏松症是一种由于骨量和骨质量下降而在晚年骨折的情况。如果骨骼在生长过程中得到最大限度的发展，年轻人将以最佳的骨骼健康开始成年，并在以后的几年里不太可能发生骨质疏松症。然而，年轻人的骨骼健康问题还没有得到充分解决。在这项应用中，我们建议延长我们为期四年的干预研究，研究高钙饮食对青春期女孩骨骼质量的影响。这项实验研究的目的是测试将膳食钙摄入量增加到1500毫克/天对提高青春期女性骨骼质量的影响。要检验的假设是：通过密度测量和超声波测量，摄入高钙饮食的青春期女性的骨骼质量将比摄入日常饮食钙的青春期女性有更大的提高。这项研究采用了一种实验设计，其中58名参与者(26名治疗组和32名对照组)将被再跟踪4.5年，总共8.5年。参与者是一个方便的样本，他们在登记时年满9岁。治疗组的女孩将继续摄入高钙食物，每天至少供应1500毫克，而对照组的女孩将被要求继续食用他们通常的饮食。在基线、每六个月和研究结束时进行测量，包括身高、体重、皮肤晒黑阶段以及病史和社会史。通常的体力活动和饮食摄入量将每三个月确定一次。在下一个周期中为这个项目提供资金将使我们能够从9岁到18.5岁持续跟踪这些年轻女性。据我们所知，这将是第一次评估最佳钙摄入量在骨量和骨质量最高时期对骨健康的影响。这群热情的青少年参与者使我们充满信心，相信我们能够成功完成这一雄心勃勃的项目。来自食物来源的钙摄入量增加对青春期女性骨骼质量有积极影响的证据将为针对青春期女性、父母和护理提供者的教育努力提供强有力的支持。否定的发现将为进一步研究最大化骨骼发育的其他伴随方法提供支持。