Core--Animal model

动物模型核心将为四个项目中的每一个项目提供体内血管生成和内皮细胞迁移的动物模型。模型将包括先前充分描述的以及最近开发的体内模型。在动物模型核心中研究的促血管生成因子和抗血管生成因子以及转基因小鼠（与野生型遗传背景回交）将由各个项目提供。核心机构成员将执行下文详述的血管生成方案。所有动物研究均将根据由每个项目的PI和动物模型核心获得的威尔医学院机构动物护理和使用委员会（IACUC）批准的动物方案进行。组织学核心成员将进行组织采集。

The animal model core will function to provide animal models of in vivo angiogenesis and endothelial migration to each of the four projects. The models will include previously well described as well as more recently developed in vivo models. The pro- and anti-angiogenic factors as well as transgenic mice (back-crossed onto wild-type genetic backgrounds) to be studied in the Animal Model Core will be provided by the individual projects. The members of the Core Facility will perform the angiogenic protocols detailed below. All animal studies will be performed under animal protocols approved by the Weill Medical College Institutional Animal Care and Use Committee (IACUC) obtained by the PIs of each project and the Animal Model Core. Members of the Histology Core will perform the harvesting of tissues.