Aging and Sympathetic Vasoconstriction: Rest vs Exercise

衰老与交感血管收缩：休息与运动

• 批准号: 6841472
• 负责人: FRANK A DINENNO
• 金额: $ 7.47万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6841472
• 关键词: aerobic exercise; age difference; aging; alpha adrenergic receptor; clinical research; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; leg; nitric oxide; oxidative stress; rest; sympathetic nervous system; vascular smooth muscle nervous control; vasoconstriction; young adult human (21-34)

DESCRIPTION (provided by applicant): Candidate: The candidate, Frank A. Dinenno, Ph.D., is a physiologist currently supported by an individual NRSA from NIA. Dr. Dinenno's previous and current research focus has been on sympathetic neural control of the circulation, with specific emphasis on how these control mechanisms are modulated by advancing age and regular physical activity in humans. His immediate goal is to acquire new research and professional skills to better prepare and help him achieve his long-term goal of developing a successful independent extramurally-funded research program on aging and cardiovascular function. This proposed KO1 should provide Dr. Dinenno the necessary training to achieve his goal. Career Development Plan: Dr. Dinenno's research career development training activities will consist of (1) acquiring new research skills associated with and complimentary to the proposed research plan; and (2) structured research- and professional skills-related activities. Environment: The environment for Dr. Dinenno's training will be outstanding. The Sponsor (Dr. Joyner) and consulting mentors are engaged in biomedical research and are extramurally-funded from NIH. All are established scientists with strong records of successful mentoring in biomedical research, three of the six are experts in aging research. Support from the General Clinical Research Center will enhance the training environment. Research: The following specific aims will be addressed: 1) to determine whether whole-leg alpha-adrenergic receptor responsiveness is reduced with age under resting conditions in healthy humans, and whether this is specific for cq- or c2-adrenergic receptors; (2) to determine whether the ability to blunt-adrenergic vasoconstriction during large muscle dynamic exercise is impaired in older adults and (3) whether this impairment is due to age-related reductions in nitric oxide bioavailability mediated via elevations in oxidative stress; and (4) to determine whether a program of regular aerobic exercise improves the ability of previously sedentary older adults to blunt sympathetic vasoconstriction at rest and during exercise. The expected results should yield new information regarding sympathetic neural control of the circulation at rest and during exercise in aging humans, and the intervention study should yield novel information about training-induced adaptations and peripheral circulatory control in older adults.

描述（由申请人提供）：候选人：候选人，弗兰克·A·丁诺（Frank A. Dinenno）博士，是一名生理学家，目前由NIA的单个NRSA支持。 Dinenno博士以前和当前的研究重点一直是对循环系统的同情神经控制，特别强调了这些控制机制如何通过增进人类的年龄和定期体育锻炼来调节这些控制机制。他的近期目标是获得新的研究和专业技能，以更好地准备并帮助他实现自己的长期目标，即制定成功的独立外部资助的衰老和心血管功能研究计划。这项提议的KO1应该为Dinenno博士提供必要的培训，以实现其目标。职业发展计划：Dinenno博士的研究职业发展培训活动将包括（1）获得与拟议的研究计划相关和免费的新研究技能； （2）结构化研究和专业技能相关的活动。环境：Dinenno博士培训的环境将非常出色。赞助商（Joyner博士）和咨询导师从事生物医学研究，并获得了NIH的壁外资金。所有人都是建立的科学家，具有成功指导生物医学研究的有力记录，六个是老化研究的专家。一般临床研究中心的支持将增强培训环境。研究：将解决以下具体目标：1）确定健康人的静息条件下的全腿α-肾上腺素能受体反应能力是否随着年龄的增长而降低，以及这是否针对CQ-或C2-肾上腺素能受体。 （2）确定老年人在大肌肉动态运动中钝化 - 肾上腺素能血管收缩的能力是否受到损害，以及（3）这种障碍是否是由于一氧化氮生物利用度与氧化应激的升高介导的一氧化氮生物利用度降低所致； （4）确定定期有氧运动计划是否提高了先前久坐的老年人在休息和运动过程中钝性交感神经收缩的能力。预期的结果应产生有关静止和运动中衰老时循环的交感神经控制的新信息，并且干预研究应产生有关训练诱导的适应性和老年人外周循环控制的新信息。