The two-edged sword: vaccines as weapons

双刃剑：疫苗作为武器

• 批准号: 6645873
• 负责人: JANET R GILSDORF
• 金额: $ 2.82万
• 依托单位: MONTEREY INST OF INTERNATIONAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645873
• 关键词: bioterrorism /chemical warfare; epidemiology; health science research analysis /evaluation; information dissemination; isolation /quarantine; literature survey; public health; recombinant DNA; vector vaccine

DESCRIPTION (provided by applicant): The terrorist attacks on the World Trade Centers and the Pentagon as well as the apparent terrorist-driven contamination of the U.S. mail with anthrax spores ushered the United States into a new era of terrorist activities on American soil. This project will integrate the expertise of the Principal Investigator, an infectious diseases clinician and microbiologist, and the expertise and resources of the Monterey Institute of International Studies in assessing the potential for the use of vaccine technologies in designing biological weapons. A systematic search and analysis of the published literature, both domestic and foreign, on live microbial vaccines, with a focus on recombinant techniques, will be used to assess the possibilities for recombinant vaccine technology to generate novel new biological weapons. Furthermore, the probability that vaccine techniques are available to or currently employed by terrorists will be determined and generalizable strategies to meet the medical and public health challenges associated with recombinant vaccine weapons will be developed.

描述（由申请人提供）：对世贸中心和五角大楼的恐怖袭击以及美国邮件明显受到恐怖分子驱动的炭疽孢子污染，使美国进入了美国本土恐怖活动的新时代。该项目将综合首席研究员、传染病临床医生和微生物学家的专门知识以及蒙特雷国际研究学院的专门知识和资源，评估在设计生物武器方面使用疫苗技术的潜力。将对国内外有关活微生物疫苗的已发表文献进行系统检索和分析，重点是重组技术，以评估重组疫苗技术产生新型生物武器的可能性。此外，还将确定恐怖分子获得或目前使用疫苗技术的可能性，并将制定可推广的战略，以应对与重组疫苗武器有关的医疗和公共卫生挑战。