MYC Oncogene Hubsite

描述(由申请人提供)： 快速涌现的关于基因表达的复杂DNA微阵列数据不仅 创造了巨大的新机遇，但也给 信息和图书馆学。我国对MYC自主研究的体会 致癌转录因子揭示了目前可访问的 信息不足以有效地掌握迅速涌现的 具有复杂数据集的出版物。PubMed不仅搜索MYC 最近的出版物发现了超过10,000条引用，产生了数百种基因 受MYC影响的人。在许多人类癌症中，MYC基因发生了改变。这个 改变的MYC基因反过来，结构性地产生一种转录因子， 调节着无数的其他靶基因。这些其他靶标表达 基因不仅取决于实验条件，还取决于细胞类型。 和物种。虽然我们的专著和众多关于MYC的特邀评论也 随着其他人在这一领域的进步，这些信息来源是 它们在印刷中很快就过时了。不断地重复是很麻烦的 通过静态、打印的审查来更新和集成最新信息 文章。因此，我们建议开发一种可自由访问的网络使能 中心将：1)提供MYC领域的历史回顾；2) 提供一个数据库，审查所有已报道的MYC目标基因和链接到 可利用的主要来源；3)对从文献中收集的数据进行注释； 以及4)基于Web的数据库，其中包含相关的、重要的负面数据 由其他调查人员提供。本网站将提供一个有用的原则证明 未来可能开发的其他相关枢纽的模式 寻找其他令人感兴趣的基因。

DESCRIPTION (provided by applicant): The rapid emergence of complex DNA microarray data on gene expression not only creates vastly new opportunities, but it also poses serious challenges for information and library sciences. Experience from our own research on the MYC oncogenic transcription factor reveals that the currently accessible information is insufficient for an efficient grasp of rapidly emerging publications with complex data sets. Not only does a PUBMED search for MYC reveal over 10,000 citations, recent publications have yield hundreds of genes that are affected by MYC. The MYC gene is altered in many human cancers. The altered MYC gene in turn, constitutively produces a transcription factor that regulates myriads of other target genes. The expression of these other target genes depends not only on the experimental conditions but also on cell types and species. While our monograph and numerous invited reviews on MYC as well as those of others have advanced the field, these sources of information are rapidly outdated as they appear in print. It is cumbersome to continuously update and integrate current information by means of static, printed review articles. As such we propose to develop a freely-accessible web-enabled hubsite that will: 1) provide a historical review of the MYC field; 2) provide a database that reviews all reported MYC target genes and links to available primary sources; 3) annotate the data collected from the literature; and 4) a web-based database of pertinent, important negative data that are provided by other investigators. This website will provide a useful proof-of principle model for other related hubsites that may be developed in the future for other genes of extraordinary high interest.