MYC Oncogene Hubsite

描述（由申请人提供）： 关于基因表达的复杂DNA微阵列数据的迅速出现不仅 创造了巨大的新机遇，但也对 信息和图书馆学。从我们自己对MYC的研究中获得的经验 致癌转录因子揭示了目前可获得的 信息不足以有效地掌握迅速出现的 具有复杂数据集的出版物。PUBMED不仅搜索MYC 在超过10，000次的引用中，最近的出版物已经产生了数百个基因， 受MYC影响的人。MYC基因在许多人类癌症中发生改变。的 改变的MYC基因反过来组成性地产生一种转录因子， 调控着无数其他靶基因。这些其他目标的表达 基因不仅取决于实验条件，而且取决于细胞类型 和物种。虽然我们的专题论文和许多关于MYC的邀请评论， 由于其他人已经推进了这一领域，这些信息来源是 很快就过时了连续地 通过静态的、打印的审查更新和整合当前信息 用品.因此，我们建议开发一个可自由访问的网络功能 该中心站点将：1）提供MYC领域的历史回顾; 2） 提供一个数据库，审查所有报告的MYC靶基因，并链接到 现有的主要来源; 3）注释从文献中收集的数据; 和4）一个基于网络的相关的，重要的负面数据， 由其他研究人员提供。这个网站将提供一个有用的原则证明 未来可能开发的其他相关枢纽站点的模型 for other genes基因of extraordinary非凡high高interest兴趣.

DESCRIPTION (provided by applicant): The rapid emergence of complex DNA microarray data on gene expression not only creates vastly new opportunities, but it also poses serious challenges for information and library sciences. Experience from our own research on the MYC oncogenic transcription factor reveals that the currently accessible information is insufficient for an efficient grasp of rapidly emerging publications with complex data sets. Not only does a PUBMED search for MYC reveal over 10,000 citations, recent publications have yield hundreds of genes that are affected by MYC. The MYC gene is altered in many human cancers. The altered MYC gene in turn, constitutively produces a transcription factor that regulates myriads of other target genes. The expression of these other target genes depends not only on the experimental conditions but also on cell types and species. While our monograph and numerous invited reviews on MYC as well as those of others have advanced the field, these sources of information are rapidly outdated as they appear in print. It is cumbersome to continuously update and integrate current information by means of static, printed review articles. As such we propose to develop a freely-accessible web-enabled hubsite that will: 1) provide a historical review of the MYC field; 2) provide a database that reviews all reported MYC target genes and links to available primary sources; 3) annotate the data collected from the literature; and 4) a web-based database of pertinent, important negative data that are provided by other investigators. This website will provide a useful proof-of principle model for other related hubsites that may be developed in the future for other genes of extraordinary high interest.