MYC Oncogene Hubsite

描述（由申请人提供）： 复杂的 DNA 微阵列数据的迅速出现不仅涉及基因表达 创造了巨大的新机遇，但也提出了严峻的挑战 信息和图书馆学。我们自己对 MYC 的研究经验 致癌转录因子揭示了目前可用的 信息不足以有效掌握快速新兴的事物 具有复杂数据集的出版物。 PUBMED 不仅搜索 MYC 揭示超过 10,000 次引用，最近的出版物产生了数百个基因 受 MYC 影响的。 MYC 基因在许多人类癌症中发生改变。的 反过来改变 MYC 基因，组成型产生转录因子 调节无数其他靶基因。这些其他目标的表达 基因不仅取决于实验条件，还取决于细胞类型 和物种。我们的专着和大量关于 MYC 的受邀评论 由于其他人已经推进了该领域，这些信息来源是 当它们出现在印刷品中时很快就过时了。连续的很麻烦 通过静态、印刷的评论来更新和整合当前信息 文章。因此，我们建议开发一个可自由访问的网络支持的 hubsite 将：1）提供 MYC 领域的历史回顾； 2） 提供一个数据库，审查所有报告的 MYC 靶基因和链接 可用的主要来源； 3）对从文献中收集的数据进行注释； 4) 一个基于网络的相关重要负面数据数据库 由其他研究者提供。该网站将提供有用的原理证明 未来可能开发的其他相关枢纽网站的模型 对于其他非常受关注的基因。

DESCRIPTION (provided by applicant): The rapid emergence of complex DNA microarray data on gene expression not only creates vastly new opportunities, but it also poses serious challenges for information and library sciences. Experience from our own research on the MYC oncogenic transcription factor reveals that the currently accessible information is insufficient for an efficient grasp of rapidly emerging publications with complex data sets. Not only does a PUBMED search for MYC reveal over 10,000 citations, recent publications have yield hundreds of genes that are affected by MYC. The MYC gene is altered in many human cancers. The altered MYC gene in turn, constitutively produces a transcription factor that regulates myriads of other target genes. The expression of these other target genes depends not only on the experimental conditions but also on cell types and species. While our monograph and numerous invited reviews on MYC as well as those of others have advanced the field, these sources of information are rapidly outdated as they appear in print. It is cumbersome to continuously update and integrate current information by means of static, printed review articles. As such we propose to develop a freely-accessible web-enabled hubsite that will: 1) provide a historical review of the MYC field; 2) provide a database that reviews all reported MYC target genes and links to available primary sources; 3) annotate the data collected from the literature; and 4) a web-based database of pertinent, important negative data that are provided by other investigators. This website will provide a useful proof-of principle model for other related hubsites that may be developed in the future for other genes of extraordinary high interest.