Asthma Clinical Research Network Center at UCSF

加州大学旧金山分校哮喘临床研究网络中心

• 批准号: 6676729
• 负责人: Homer A Boushey
• 金额: $ 106.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6676729
• 关键词: asthma; beta adrenergic agent; clinical research; clinical trials; combination therapy; cooperative study; corticosteroids; human therapy evaluation; information display; inhalation drug administration; macrolide antibiotics; microarray technology; patient care management; patient oriented research; pharmacokinetics; respiratory disorder chemotherapy; respiratory infections

DESCRIPTION (provided by applicant): Investigators at the University of California, San Francisco here apply to participate in a cooperative research network examining current and novel therapies and management strategies for adult asthma and disseminating its findings to the medical community. The need for this network is demonstrated by asthma's rising morbidity and cost, by advances in basic research on its pathogenesis, and by the development of potentially effective but also potentially costly new therapies. Defining the place of these therapies will require large collaborative, multi-center studies. This application proposes two studies that address issues of current clinical importance and that incorporate new approaches to examining mechanisms of disease. The first project examines whether the effects of an inhaled corticosteroid on "airway remodeling" are dose-dependent, whether they are enhanced by the addition of a long-acting beta-agonist, and whether changes in measures of remodeling are related to changes in the levels of expression of genes for products thought to regulate collagen deposition and mucus production. The new technologies used in this study include design-based stereology for quantitative morphometry of bronchial biopsies and transcription profiling of gene expression in bronchial epithelial cells. The second project examines whether the addition of a macrolide antibiotic to usual care alters important outcomes in asthma exacerbations, especially in the subgroups currently most often treated, like those with purulent sputum or symptoms of sinusitis. This study will offer an opportunity to examine the validity of a microarray-based approach to detecting respiratory pathogens, developed in the UCSF Department of Biochemistry/Biophysics. To conduct these and other Asthma Clinical Research Network studies, we propose to draw from an established database of > 5000 patients with asthma who have participated in - or expressed an interest in participating in - clinical trials. Finally, we propose a Clinical Research Skills Development program for new appointees to the Pulmonary and Allergy Divisions, to foster their skills in clinical research and in genomic-based technologies.

描述(由申请人提供)： 加州大学旧金山分校的研究人员申请加入一个合作研究网络，检查成人哮喘目前和新的治疗方法和管理策略，并将其结果传播给医学界。哮喘发病率和成本的上升，对其发病机制的基础研究的进展，以及潜在有效但可能代价高昂的新疗法的开发，证明了对这一网络的需求。确定这些疗法的位置将需要大型合作、多中心研究。 这项申请提出了两项研究，这两项研究解决了当前临床上重要的问题，并纳入了检查疾病机制的新方法。第一个项目研究吸入皮质类固醇对“呼吸道重塑”的影响是否具有剂量依赖性，是否通过添加长效的β-激动剂而增强，以及重塑测量的变化是否与被认为调节胶原沉积和粘液产生的产品的基因表达水平的变化有关。这项研究中使用的新技术包括基于设计的体视学用于支气管活检组织的定量形态计量和支气管上皮细胞基因表达的转录图谱。第二个项目考察了在常规治疗中增加大环内酯类抗生素是否会改变哮喘恶化的重要结局，特别是在目前最常治疗的亚组中，如有化脓性痰或鼻窦炎症状的亚组。这项研究将提供一个机会来检验加州大学旧金山分校生物化学/生物物理系开发的基于微阵列的检测呼吸道病原体的方法的有效性。为了进行这些和其他哮喘临床研究网络研究，我们建议从已建立的数据库中提取已参与或表示有兴趣参与临床试验的5000名哮喘患者。 最后，我们建议为肺科和过敏科的新入职人员提供临床研究技能发展计划，以培养他们在临床研究和基于基因组的技术方面的技能。