OCULAR HYPERTENSION TREATMENT STUDY (OHTS)

这是一份支持我们组织成为 参与高眼压治疗研究的临床中心 （OHTS）。OHTS是一项多中心随机分配临床试验 旨在检验以下假设： 压力可防止或延迟昏迷性视觉系统的发作 高眼压患者的损害。OHTS的完整细节 基本原理、设计和方法在OHTS铅应用中， 程序手册。 本建议书提供了委托人能力的证明文件 研究者和合作研究者筛选足够数量的 高眼压患者招募至少100名患者， 24-月期间。我们将在下列组织的赞助下组织这项工作： 大学眼科顾问研究和教育基金会 在华盛顿。 我们致力于OHTS的必要性和合理性。我们包括 通过此应用程序文档， 根据OHTS的细节进行雅阁的组织 程序手册。我们的大部分入组患者将来自我们的 私人青光眼专科诊所。我们已经运作了 晚期青光眼干预研究（Advanced Glaucoma Intervention Study，AGIS）我们 使这一正常运作的组织参加我们提议的 OHTS。在我们的研究计划中，我们将我们所在地区的组织列为潜在组织。 患者入组和随机化的外部转诊来源 在OHTS治疗。我们与这些组织的关系是 建立;他们一直在我们的AGIS活动的生产来源。

This is an application for support for our organization to become a participating Clinical Center in the Ocular Hypertension Treatment Study (OHTS). The OHTS is a multicenter random assignment clinical trial designed to test the hypothesis that medical reduction of intraocular pressure prevents or delays the onset of glaucomatous visual system damage in ocular hypertensive patients. The complete details of the OHTS rationale, design, and methods are in the OHTS lead application and Manual of Procedures. This proposal provides documentation of the ability of the Principal Investigator and the Coinvestigators to screen sufficient numbers of ocular hypertensive individuals to enroll at least 100 patients over a 24-month period. We shall organize for this effort under sponsorship of the University Ophthalmic Consultants Research and Educational Foundation of Washington. We are committed to the need and justification of the OHTS. We include with this application documentation of the capabilities of our organization to conduct the study in accord with the details of the OHTS Manual of Procedures. Most of our enrolled patients will come from our private, glaucoma subspeciality practices. We have already functioned successfully for the Advanced Glaucoma Intervention Study (AGIS). We bring that functioning organization to our proposed participation in the OHTS. In our Research Plan we list organizations in our area as potential outside referral sources for patients for enrollment and randomization to treatment in the OHTS. Our relationship with these organizations is established; they have been productive sources in our AGIS activity.