IMPROVEMENT OF ANIMAL HEALTH PROGRAM

这项申请申请资金，以满足洛克菲勒大学改进集中式实验动物计划的短期和长期目标。要求为三个主要项目提供资金，每个项目都对动物健康有重大影响。这些措施包括安装一个接近阅读卡的房间进入系统，提供一个对运动敏感的晚间灯光覆盖系统，以及安装通风架子，将动物安置在微型隔离笼子中。有限制的房间出入将提供更高水平的生物安全，减少无意中房间污染的机会，并作为调整房间卫生时间表的监测装置。运动敏感的灯光覆盖将使用晚间红灯系统，将入侵对夜间周期的影响降至最低，从而使动物处于更具生理性的状态。通风的笼子通过HEPA过滤的送风提高了微环境安全性，通过增加空气交换减少了笼子内有害气体的积累，并允许更高效的住房。后一个系统还将容纳来自卫星设施的动物，同时一个新的中央设施正在建设中。

This application requests funds to meet the short- and long-term goals of The Rockefeller University's improvement of the centralized laboratory animal program. Funds are requested for three major projects, each of which has substantial implications for animal health. They include the installation of a proximity card-reading room access system, provision of a motion-sensitive evening room light over-ride system, and installation of ventilated racks housing animals in microisolator cages. Restrictive room access will provide a higher level of biosecurity, reduce opportunities for inadvertent room contamination, and serve as a monitoring device to adjust room sanitation schedules. Motion-sensitive light over-rides will use an evening red light system to minimize the impact of intrusion on nocturnal cycles, thus maintaining animals in a more physiological state. The ventilated caging increases microenvironmental safety through HEPA-filtered supply air, reduced in-cage noxious gas accumulation via increased air changes, and allows for more efficient housing. The latter system will also accommodate animals from a satellite facility while a new central facility is under construction.