Epigenetic mechanisms of brain dysfunction in psychotic and mood disorders

精神病和情绪障碍中脑功能障碍的表观遗传机制

• 批准号: nhmrc : 1081603
• 负责人: A/Pr Melissa Green
• 金额: $ 41.2万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-mechanisms-brain-mood-disorders/518819
• 关键词: Epigenetic; mechanisms; brain; dysfunction; psychotic

This project investigates the role of epigenetic processes (i.e., functional changes to the genome affecting gene expression) in mediating the long-term effects of childhood trauma in schizophrenia and bipolar-I disorder. We specifically aim to distinguish the effects of trauma-related epigenetic effects on brain structure and function, and on the immune and stress-response systems, and the potential moderation of these effects by structural genetic variants associated with psychosis risk.

该项目研究表观遗传过程的作用（即，影响基因表达的基因组的功能变化）在调节精神分裂症和双相I型障碍的儿童期创伤的长期影响中的作用。我们的具体目标是区分创伤相关的表观遗传效应对大脑结构和功能的影响，以及对免疫和应激反应系统的影响，以及与精神病风险相关的结构遗传变异对这些影响的潜在调节作用。