Epigenetic predictors of outcome in malignant glioma

恶性神经胶质瘤结果的表观遗传学预测因子

• 批准号: nhmrc : 1049609
• 负责人: A/Pr Elizabeth Algar
• 金额: $ 46.52万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-predictors-outcome-malignant-glioma/112098
• 关键词: Epigenetic; predictors; outcome; malignant; glioma

Human high grade gliomas (HGG) present as heterogeneous disease, primarily defined by the histologic appearance of the tumor cells.Glioblastoma multiforme (GBM) is the most common illness and continues to have a very poor prognosis, despite the use of multimodality therapy including surgery, radiation therapy and chemotherapy. We will use our existing biobank of specimens, clinical information and molecular investigation to identify factors that determine outcomes.

人类高级别胶质瘤（HGG）是一种异质性疾病，主要由肿瘤细胞的组织学表现来定义，多形性胶质母细胞瘤（GBM）是最常见的疾病，尽管采用了包括手术、放疗和化疗在内的综合治疗，其预后仍然很差。我们将使用我们现有的标本生物库，临床信息和分子研究来确定决定结果的因素。