Epigenetic regulation of germline fate during embryonic development and oncogenesis

胚胎发育和肿瘤发生过程中种系命运的表观遗传调控

• 批准号: nhmrc : GNT1162993
• 负责人: Dr Ozren Bogdanovic
• 金额: $ 43.7万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-germline-development-oncogenesis/1349368
• 关键词: Epigenetic; regulation; germline; fate; during

During embryogenesis genes are switched on and off by a variety of molecular mechanisms. One such gene-silencing mechanism is DNA methylation. This chemical modification mostly targets germline-specific genes in early embryos. In adults, the loss of this mark and the reactivation of this set of genes has been observed in many cancers including melanoma, hepatic and lung cancer. Here I aim to explore the molecular underpinnings of these events and determine their role in cancer formation.

在胚胎发生过程中，基因通过各种分子机制开启和关闭。其中一种基因沉默机制是DNA甲基化。这种化学修饰主要针对早期胚胎中的种系特异性基因。在成人中，这一标记的丢失和这组基因的重新激活已经在许多癌症中观察到，包括黑色素瘤、肝癌和肺癌。在这里，我的目标是探索这些事件的分子基础，并确定它们在癌症形成中的作用。