Diverse Nitrogen Heterocycle Synthesis Using Nickel Catalysis

杂环化合物在生物活性化合物中普遍存在。因此，高效制备杂环化合物是制药、农化等行业的重要目标。虽然制备杂环的方法很多，但许多方法都局限于制备一种特定类型的杂环。使用相同的基本反应和催化剂体系来获得许多不同种类的杂环化合物的新方法，将使化学更容易在新的场景中可视化和实施，因此将是高度可行的。本项目旨在实现这一目标，并提出开发我们小组最近发现的新的镍催化反应，用于合成各种杂环化合物。

Heterocycles are ubiquitous in biologically active compounds. Therefore, preparing heterocycles efficiently is a vitally important goal in sectors such as the pharmaceutical and agrochemical industries. Although there are numerous methods to prepare heterocycles, many are limited to the preparation of one particular type of heterocycle. New methods that give access to many different classes of heterocycles using the same basic reaction and catalyst system would render the chemistry easier to visualise and implement in new scenarios, and would therefore be highly enabling. This project aims to achieve this goal, and proposes to develop new nickel-catalysed reactions recently discovered in our group for the synthesis of diverse heterocycles.