Making and breaking of the medial entorhinal grid cell symmetry

目前，人们对位置细胞和网格细胞在空间记忆导航中的功能作用知之甚少。例如，人们对网格细胞和位置细胞如何对导航新环境做出反应和调整仍然知之甚少。该项目的目的是对新环境下的网格细胞模式和位置细胞场形成进行系统的研究。此外，该项目旨在研究这两种细胞类型相互作用以产生新环境空间表征的机制。这将通过在动物觅食新环境时，从海马CA1区和/或内侧内嗅皮层（mEC）进行长时间的电生理记录来实现。这项研究的成功将有助于我们进一步了解海马体旁空间网络，以及它如何支持导航和情景记忆。

Currently, little is known about the functional role of place cells and grid cells in spatial memory navigation. For example, it remains poorly understood how grid cells and place cells respond and adjust to navigating novel environments. The aim of the proposed project is to conduct a systematic investigation of grid cell pattern and place cell field formation in novel environments. Furthermore, this project aims to investigate the mechanisms by which these two cell types interact to produce spatial representations of novel environments. This will be achieved by performing electrophysiological recordings over an extended period of timer from the CA1 region of the hippocampus and/or the medial entorhinal cortex (mEC) while the animal forages a novel environment. The success of this research will serve to further our knowledge of the parahippocampal spatial network and how does it support navigation and episodic memory.