Epigenetic regulation of thyroid function

甲状腺功能的表观遗传调控

• 批准号: nhmrc : GNT1087407
• 负责人: A/Pr Scott Wilson
• 金额: $ 86.9万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-thyroid-function/1345701
• 关键词: Epigenetic; regulation; thyroid; function

Thyroid hormones are regulators of development and metabolism. The lack of concordance of thyroid function and disease in identical twins suggests that environmental effects have a significant role. Quantifying epigenetic modifications, such as DNA methylation, has the potential to identify causal effects from the environment. This research will provide a comprehensive database of DNA methylome alterations that will contribute important insights into thyroid function in health and disease.

甲状腺激素是发育和新陈代谢的调节剂。同卵双胞胎的甲状腺功能和疾病缺乏一致性表明环境影响起着重要作用。量化表观遗传修饰（例如 DNA 甲基化）有可能识别环境的因果影响。这项研究将提供 DNA 甲基化组改变的综合数据库，这将为了解健康和疾病中的甲状腺功能提供重要见解。