Mapping spatial working memory and attention in cortex

绘制皮质空间工作记忆和注意力图

• 批准号: 6649099
• 负责人: DONALD J HAGLER
• 金额: $ 4.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-05 至 2006-04-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6649099
• 关键词: attention; behavioral /social science research tag; brain mapping; clinical research; human subject; nuclear magnetic resonance spectroscopy; parietal lobe /cortex; postdoctoral investigator; prefrontal lobe /cortex; retina; saccades; short term memory; sound perception; space perception; visual perception

DESCRIPTION (provided by applicant): Patients with brain damage to the parietal, frontal, and prefrontal cortex often have deficits in spatial working memory and attentional processes. The goal of this investigation is to clarify the function of these various brain regions in the working memory of spatial location and the generation of saccades, or rapid eye movements, toward those locations. There are three specific aims: 1. Determine if retinotopy of visually-guided and delayed saccades exists in frontal cortical areas. 2. Determine if there are topographic maps in higher cortical areas of remembered target angle for auditory targets. 3. Determine if there are topographic maps in higher cortical areas of remembered target angle when a joystick is moved toward visual and auditory cues. Brain activity will be measured using functional magnetic resonance imaging. Subjects will be presented with visual cues via a mirror reflection of a projected image. Auditory cues will be presented through headphones with proper interaural differences in timing, sound level, and spectral composition, in order to simulate sounds originating in three dimensional space. After a delay period, subjects will make a saccade or joystick movement toward the remembered location of the stimulus. Brain activity correlated with stimulus location will be used to identify those higher cortical regions that display topographic maps of unimodal or multimodal sensory space. This project is an investigation into the neurobiological basis for memory of and attention to spatial location.

描述(由申请人提供)：大脑顶叶、额叶和前额叶皮质受损的患者通常在空间工作记忆和注意力过程方面存在缺陷。这项研究的目的是阐明这些不同的大脑区域在空间位置工作记忆中的功能，以及朝向这些位置的眼跳或快速眼动的产生。有三个具体目标：1.确定前额皮质区是否存在视觉引导和延迟性眼跳的视网膜复视。2.确定听觉目标在记忆目标角度的较高皮质区域是否有地形图。3.确定当操纵杆朝视觉和听觉提示移动时，在记忆的目标角度的较高皮质区是否有地形图。大脑活动将使用功能磁共振成像进行测量。受试者将通过投影图像的镜面反射获得视觉提示。听觉提示将通过耳机呈现，在计时、声级和频谱组成方面具有适当的耳间差异，以模拟源自三维空间的声音。在延迟一段时间后，受试者会朝刺激的记忆位置跳起或移动操纵杆。与刺激位置相关的大脑活动将被用来识别那些显示单模式或多模式感觉空间地形图的高级皮质区域。这个项目是关于记忆和注意空间位置的神经生物学基础的研究。