Epigenetic therapies as molecular probes to investigate the molecular pathogenesis of leukaemia

癌症靶向治疗成功的一个主要限制是，我们几乎没有工具来详细研究它们在癌细胞和正常细胞中的作用机制。如果我们能够在细胞内可视化这些药物，并准确地描述与这些疗法相互作用的细胞内的蛋白质、DNA和RNA，我们就能够确定能够优化其疗效并减少这些疗法副作用的策略。

A major limitation to the success of targeted therapies in cancer is the fact that we have few if any tools to study in detail their mechanism of action within cancerous and normal cells. If we were able to visualise these drugs within cells and precisely characterise the proteins, DNA and RNA within a cell that interact with these therapies we will be able to identify strategies that can optimise their efficacy and reduce the side-effects of these treatments.