Activating and directing post-translational modification by the design and synthesis of heterobifunctional small molecules
Activating and directing post-translational modification by the design and synthesis of heterobifunctional small molecules
通过设计和合成异双功能小分子激活和指导翻译后修饰
批准号：
2119117
负责人：
金额：
$0.0万
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2018
资助国家：
英国
项目状态：
已结题
起止时间：
2018 至 --
中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Overall aim:Demonstrate that heterobifunctional ligands can enable selective post-translational modification of a target protein by bringing together two protein components.Required steps:Design and synthesis of heterobifunctional ligands Test for binding to individual proteins; check cell permeability; refine design as necessaryCheck for phosphorylation of target proteinConfirm activation by looking at downstream or phenotypic effects
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
海外基金
