GENE THERAPY TRAINING

描述：（申请人的摘要）UW/FHCRC的培训计划 PEGT支持医学博士的职业发展，医学博士/博士和博士科学家 对基因治疗或相关医学领域感兴趣。 它主要是为博士后和临床研究员参加 在研究项目支持的PEGT，但也将提供给 通过其他方式资助或与其他基因治疗有关的研究员 研究项目。这个项目的目标是培养科学家 在基因治疗领域成功独立的职业来实现这一点 通过一系列机制，包括正式课程、研究研讨会、 参与性活动、实验室和临床研究，以及 申请奖学金。重点将放在 了解基因的分子和细胞生物学， 转移，以及疾病过程的科学基础。研究员将 还可以通过接触和参与翻译研究来进行培训， 临床基因治疗试验，并在设计和教学课程的工作， 临床试验的伦理学。这种基础研究和应用研究的结合 培训的目的是培养基因领域的杰出科学家， 能够促进我们对疾病过程的理解， 设计基因疗法，并在临床试验中实施这些进展。 培训计划的大部分内容已经到位，PEGT将使我们能够 将各种培训机会整合到一个连贯的计划中。 方案的现有内容包括方案的定期会议， 项目"血红蛋白病的干细胞基因治疗"，定期 由NIDDK支持的基因治疗组织的会议和研讨会 中心，西雅图基因治疗俱乐部，马基分子研讨会 医学中心，生物医学研究诚信系列，研讨会 由基础科学部门组织，不同的医学大 轮此外，培训学院在以下方面具有丰富的经验： 其他成功的培训项目，包括分子医学项目， 医学遗传学、肿瘤学和血液学。

DESCRIPTION: (Applicant's Abstract) This Training Program of the UW/FHCRC PEGT supports the career development of M.D., M.D./Ph.D. and Ph.D. scientists interested in a career in gene therapy or related fields of academic medicine. It is intended primarily for post-doctoral and clinical fellows participating in research projects supported by the PEGT, but will also be available to fellows funded through other means or associated with other gene therapy-related research projects. The goal of this program is to train scientists for successful, independent careers in gene therapy. This is accomplished through a set of mechanisms including formal courses, research seminars, participatory activities, laboratory and clinical research, and submission of applications for fellowship funding. A strong emphasis will be placed on obtaining an understanding of the molecular and cellular biology of gene transfer, as well as the scientific basis of disease processes. Fellows will also be trained in translational research by exposure to and participation in clinical gene therapy trials, and didactic course work on the design and ethics of clinical trials. This combination of basic and applied research training is intended to develop outstanding scientists in the field of gene therapy that are able to advance our understanding of disease processes, design genetic therapies, and implement these advances in clinical trials. Much of the Training Program is already in place, and the PEGT will allow us to coordinate the various training opportunities into a coherent program. Existing elements of the Program include the regular meetings of the Program Project "Stem Cell Gene Therapy of the Hemoglobinopathies," the regular meetings and the seminars organized by the NIDDK-supported Gene Therapy Center, the Seattle Gene Therapy Club, the Seminars of the Markey Molecular Medicine Center, the Biomedical Research Integrity Series, the seminars organized by Basic Sciences Departments, and the different Medical Grand Rounds. In addition, the Training Faculty has significant experience with other successful training programs, including programs in Molecular Medicine, Medical Genetics, Oncology, and Hematology.