ETIOLOGY AND CONSEQUENCES OF ADOLESCENT DRUG USE

这是K 05高级科学家奖的竞争延续申请。 主要目标是继续并扩大关于以下方面的研究：（1）青少年吸毒的开始、稳定和变化所涉及的风险和保护因素;（2）吸毒途径的测试模型;（3）吸毒对年轻成年人机能的后果。 拟议的研究将通过以下方式扩大和扩展先前的研究：（1）纳入市中心青少年和静脉吸毒者子女的样本;（2）研究易吸毒特征的代内和代间传播;（3）检查与艾滋病传播行为和应对艾滋病有关的因素。 为了实现这些目标，目前正在进行一项综合研究方案，涉及五个大规模项目：（一）从1-10岁开始，对五个时间点的儿童及其母亲进行纵向研究;（二）对项目一中最初研究儿童的两岁后代进行多代研究;（三）对市中心非裔美国人和波多黎各青少年进行研究;（四）对儿童及其母亲的研究。（四）对生活在南美洲哥伦比亚的青少年及其母亲的研究;（五）对使用静脉注射毒品的父亲及其子女的艾滋病毒阳性和阴性研究。 这一综合研究计划的主要意义在于，它解决了药物领域的许多关键问题，例如，在儿童期到青年期的整个发育阶段，使用毒品有哪些风险;什么可以防止这些风险;风险和保护因素如何在最有可能参与毒品或其他问题行为的人群中发挥作用，包括那些与艾滋病传播有关的人群;如何才能阻止风险从一代人传递到下一代人;以及如何避免或减轻吸毒的后果。 K 05将使我能够把我的全部时间和精力投入到研究目标，如实质性和方法的发展，与其他纵向研究的调查人员合作，指导活动，包括高中和研究生，医科学生和初级教师的指导。

This is a competing continuation application for a K05 Senior Scientist Award. The major goals are to continue and extend research on: (1) risk and protective factors involved in onset, stability and change in adolescent drug use; (2) testing models of pathways to drug use; and (3) consequences of drug use on young adult functioning. The proposed research will expand on and extend prior research by: (1) inclusion of samples of inner city youngsters and children of IV drug abusers; (2) study of intra- and intergenerational transmission of drug-prone characteristics; and (3) examination of factors related to AIDS transmission behavior and to coping with AIDS. In order to achieve these goals, an integrated program of research is underway involving five large-scale projects: (I) A longitudinal study of children and their mothers seen at five points in time beginning at ages 1-10; (II) A multigenerational study of two- year-old offspring of the original study child in Project I; (III) A study of inner city African-American and Puerto Rican adolescents; (IV) A study of adolescents and their mothers living in Columbia, South America; and (V) a study of HIV plus and HIV minus intravenous drug using fathers and their children. The major significance of this program of integrated research is that it addresses many critical issues in the drug field, e.g., what are the risks for drug use throughout the developmental span of childhood to young adulthood; what can protect against these risks; how do risk and protective factors operate in populations most likely to become involved in drug or other problem behaviors, including those implicated in the spread of AIDS; how can one break the transmission of risk from one generation to the next; and how can the consequences of drug use be averted or lessened. The K05 will enable me to devote my full time and energy to research goals such as substantive and methodological development, collaboration with investigators in other longitudinal studies, mentoring activities including guidance of high school and graduate students, medical students, and junior faculty.