New Psychometric Methods for Substance Abuse Research

描述：（申请人提供） 这是K 05高级科学家研究职业奖（RCA）的申请， #5 K 05 DA 00017的竞争延续。建议的具体目标 五年研究计划如下： 1.为药物滥用研究开发新的心理测量方法; 2.将这些新开发的方法应用于重要的药物滥用数据集; 3.切实改进方法; 4.创建非技术论文和教程，以改进药物治疗方法 滥用研究;以及 5.向药物滥用和健康研究人员及政府机构提供以下建议： 方法论 该研究计划旨在开发新的多元 心理测量和统计技术，持有特别承诺，为改善 心理、社会、行为、流行病学和 关于药物使用和滥用的功能成像健康相关研究。方法 稳健地分析实验性和非实验性药物滥用数据， 包含选择性、离群值情况、任意分布、 测量，非标准抽样计划，小样本，相关观测， 等将开发。特别注意结构方程 模型，可能涉及潜在变量的调解和主持人的关系。 最优小样本，缺失数据，稳健，多水平非正态，bootstrap， 功能成像，超级计算机的研究方法是一个特别的重点。而 这项赠款不会收集任何数据，新开发的技术将 对它们与药物滥用研究的实际相关性进行广泛评价 根据高质量数据处理药物滥用方面的重要实质性问题 与NIDA/UCLA计划项目资助P01 DA 01070联合获得，通过 与脑图谱研究人员和国家活性物质合作 虐待研究人员在自己的项目工作，以及通过合作， NIDA和其他卫生相关机构。在此基础上开发的方法 赠款也将广泛传播。

DESCRIPTION: (provided by applicant) This is a request for a K05 Senior Scientist Research Career Award (RCA) as a competing continuation of #5 K05 DA00017. The specific aims of the proposed five-year research program are the following: 1. Develop new psychometric methods for drug abuse research; 2. Apply these newly developed methods to important drug abuse data sets; 3. Generate practical improvements in methodology; 4. Create nontechnical papers and tutorials to improve methodology in drug abuse research; and 5. Advise drug abuse and health researchers and government agencies on methodology. The research program is directed towards the development of new multivariate psychometric and statistical techniques that hold special promise for improving the quality of psychosocial, social, behavioral, epidemiological, and functional imaging health-related research on drug use and abuse. Methods for robustly analyzing experimental and nonexperimental drug abuse data that may contain selectivity, outlier cases, arbitrary distributions, errors in measurement, nonstandard sampling plans, small samples, dependent observations, etc. will be developed. Special attention is given to structural equation models that may involve latent variables in mediation and moderator relations. Optimal small sample, missing data, robust, multilevel nonnormal, bootstrap, functional imaging, supercomputer research methods are a special focus. While no data will be gathered under this grant, the newly developed techniques will be extensively evaluated for their practical relevance to drug abuse research by addressing important substantive issues in drug abuse on high-quality data obtained in association with NIDA/UCLA program project grant P01 DA01070, via collaboration with brain mapping researchers and nationally active substance abuse researchers working on their own projects, as well as by cooperation with NIDA and other health-related agencies. Methods that are developed under this grant also will be widely disseminated.