POSITRON TOMOGRAPHY IN ISCHEMIC HEART DISEASE

正电子断层扫描在缺血性心脏病中的应用

• 批准号: 6650856
• 负责人: HEINRICH R SCHELBERT
• 金额: $ 61.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650856
• 关键词: adenosine; bioimaging /biomedical imaging; clinical research; comorbidity; coronary disorder; disease /disorder proneness /risk; early diagnosis; estrogens; female; heart circulation; heart imaging /visualization /scanning; hormone therapy; human subject; insulin sensitivity /resistance; myocardial ischemia /hypoxia; noninsulin dependent diabetes mellitus; noninvasive diagnosis; positron emission tomography; postmenopause; progestins; radionuclides; vasomotion

DESCRIPTION (Adapted from Applicants Abstract): The research proposed in this application employs measurements of myocardial blood flow (MBF) with 13N ammonia and PET in patients with coronary risk factors but without coronary artery disease in order to detect noninvasive alterations in coronary vasoreactivity as likely events early in the evolution of coronary atherosclerosis. Specifically, it will test with adenosine the total integrated coronary vasomotor function and, more specifically, through responses of MBF to cold pressor testing the predominantly endothelial dependent coronary vasoreactivity. The past and preliminary observations support the feasibility of this approach for exploring coronary vasomotion. PET based measurements are unique to this study because MBF measurements in absolute units are required which are not possible with more conventional approaches in two types of patients, one with insulin resistance and Type-II-Diabetes and a second one of postmenopausal women with coronary risk factors. In the diabetic patients the applicants will also determine coronary artery calcium scores with EBCT in order to compare alterations in vasomotor function and structural changes as well as their time dependent progression and whether the possible progression of insulin resistance to Type-II-Diabetes can be demonstrated and whether rigorous anti-diabetic control possibly in conjunction with lipid lowering can retard this progression. In the postmenopausal women, the applicants will explore protective effects of estrogens and examine whether this effect is negated or modified by progestins and its different forms and further, whether adequate protection requires addition of statins and anti-oxidants. If successful, the observation could lay the foundation for larger prospective clinical trials and, most importantly, provide new insights into the early atherogenic process as well as possibilities to beneficially influence its progression.

描述（改编自申请人摘要）：本申请中提出的研究 应用采用13N的心肌血流量（MBF）测量 有冠状动脉危险因素但无冠状动脉病变的患者中的氨和PET 为了检测冠状动脉的非侵入性改变， 血管反应性作为冠状动脉病变早期的可能事件 动脉粥样硬化具体地说，它将测试与腺苷的总集成 冠状动脉血管功能，更具体地说，通过MBF对 冷加压试验主要是内皮依赖性冠状动脉 血管反应性过去和初步的观察结果都支持这一可行性 探索冠状动脉血管运动的方法。基于PET的测量 本研究独一无二，因为需要以绝对单位测量MBF 这在两种类型的更传统的方法中是不可能的， 患者，一个患有胰岛素抵抗和II型糖尿病，另一个患有 有冠心病危险因素的绝经后妇女。在糖尿病患者中， 申请人还将使用EBCT确定冠状动脉钙化评分， 为了比较血管功能和结构变化的变化， 以及它们的时间依赖性进展以及可能的进展 胰岛素抵抗的II型糖尿病可以证明， 严格的抗糖尿病控制可能与降脂结合， 延缓这一进程。在绝经后妇女中，申请人将 探索雌激素的保护作用，并检查这种作用是否 被孕激素及其不同形式否定或修饰， 充分的保护需要添加他汀类药物和抗氧化剂。如果 如果成功，观测可以为更大的前景奠定基础。 临床试验，最重要的是，提供了新的见解， 动脉粥样硬化过程以及可能性，以有利地影响其 进展