DISSECTING THE RELATIONSHIP BETWEEN PHOSPHINOSITIDE3-KINASE ACTIVITY AND L-SELECTIN EXPRESSION BY LEUCOCYTES
DISSECTING THE RELATIONSHIP BETWEEN PHOSPHINOSITIDE3-KINASE ACTIVITY AND L-SELECTIN EXPRESSION BY LEUCOCYTES
剖析磷酸肌醇 3 激酶活性与白细胞 L-选择素表达之间的关系
批准号：
2125608
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金额：
$0.0万
依托单位：
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2018
资助国家：
英国
项目状态：
已结题
起止时间：
2018 至 --
中文摘要
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英文摘要
The classical view of L-selectin function in T cell homing was restricted to naïve and central memory trafficking to lymph nodes; however our new data has overthrown this dogma. We have shown that CD8+ T cell dependent virus clearance from infected organs is limited by the level of L-selectin expression on early stage effector T cells and maintaining high L-selectin levels (gain of function) boosts CD8+T cell immunity.
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