Magnetic Resonance Elastography in Breast Cancer

乳腺癌的磁共振弹性成像

• 批准号: 6609794
• 负责人: Richard L. Ehman
• 金额: $ 28.93万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-08 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6609794
• 关键词: bioimaging /biomedical imaging; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; diagnosis design /evaluation; female; human subject; magnetic resonance imaging; noninvasive diagnosis; phantom model; women's health

DESCRIPTION (Provided by Applicant): Mortality from breast cancer is stage-dependent and thus, early detection is vital if we are to make progress addressing the burden of this disease. Imaging methods such as mammography have made a ma contribution in the early diagnosis of breast cancer. Yet is clear that the standard imaging techniques have significant limitations in detecting the earliest changes of breast cancer and in distinguishing benign condition from important premalignant and malignant disease. Based on the remarkable efficacy of simple palpation as a clinical tool for detecting cancer in accessible parts of the body, it has long been recognized that a sensitive, imaging-based method, capable of assessing viscoelastjc properties of tissue, might offer considerable potential for discriminating malignant from benign tissues. The goal of this research is to develop a practical noninvasive MRJ-based method for quantitatively evaluating the mechanical properties of breast tissues. We call this technique magnetic resonance elastography (MRE). Preliminary development of MRE in our laboratory has demonstrated the feasibility of quantitatively imaging the large differences in the elastic properties of normal and cancerous breast tissues in vivo. The specific aims of this proposal are (1) to further develop the MR elastography technology for pre imaging and (2) to assess the potential of this new imaging technique to differentiate breast malignancies fr non-malignant lesions. The MRE technique is implemented on a standard MRI scanner. Therefore it is readily combined in the same examination with standard contrast-enhanced MRI protocols for breast cancer imaging. This research-will provide the first substantial body of quantitative, spatially-resolved data describing the viscoelastic properties of benign and malignant breast tissues in vivo. The planned technical development work and pilot studies will provide critical prerequisites for determining the advisability and most efficient design of a future clinical trial to test the value of MRE for distinguishing benign from malignant breast masses.

描述（由申请人提供）：乳腺癌的死亡率是 因此，如果我们要取得进展，早期发现至关重要 解决这种疾病的负担。成像方法，如乳房X线摄影， 在乳腺癌的早期诊断方面做出了巨大贡献。但很明显 标准的成像技术在检测 乳腺癌的最早期改变及鉴别良性病变 重要的癌前病变和恶性病变。 基于简单触诊作为临床工具的显著功效， 检测身体可触及部位的癌症， 一种灵敏的，基于成像的方法，能够评估粘弹性， 组织的性质，可能提供相当大的潜力， 恶性组织与良性组织。本研究的目的是开发一种 一种基于MRJ的实用非侵入性方法，用于定量评估 乳腺组织的机械性能。我们称这种技术为磁性 共振弹性成像（MRE）。本实验室磁共振成像的初步研究 已经证明了定量成像的可行性 正常和癌性乳腺组织的弹性特性的差异， vivo. 这项建议的具体目的是：（1）进一步发展MR 用于预成像的弹性成像技术，以及（2）评估该技术的潜力 鉴别乳腺良恶性肿瘤的新影像学技术 病变 MRE技术在标准MRI扫描仪上实现。因此 易于与标准对比增强MRI在同一检查中结合 乳腺癌成像的协议。这项研究将提供第一个 大量的定量的、空间分辨的数据描述了 良性和恶性乳腺组织在体内的粘弹性。的 计划中的技术开发工作和试点研究将提供关键的 确定可重复性和最有效设计的先决条件 未来的临床试验，以测试MRE的价值，以区分良性和 乳腺恶性肿块