High Resolution, High Sensitivity CT Imager
高分辨率、高灵敏度 CT 成像仪
基本信息
- 批准号:6692312
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-08-01 至 2004-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
The goal of this proposal is to develop dedicated, high resolution, computer tomography (CT) equipment for examination of excised specimens during surgical breast biopsies and surgical breast conserving therapies. The localization of lesion margins relative to the specimen margins, and estimating the orientation and extent of lesions that may extend beyond the specimen margins is of paramount importance during the surgical procedure. The radiological examination of the specimens needs to be performed very quickly within a few minutes in order to give surgeons the required feedback and to minimize the duration of the operation.
The radiological examination of the excised specimens to aid during surgery is common practice in the US and worldwide. However, the equipment used in these procedures is not optimized for this task. Currently used equipment lacks the required contrast and does not have high enough spatial resolution for sufficient differentiation of tissues based on physical density and effective atomic number. For these reasons, we propose a new approach which combines development of a new, high resolution digital imaging detector based on Hgl2 polycrystalline x-ray converter coupled to a silicon CMOS readout circuit and use of a computer tomographic imaging technique for further enhancement of the image contrast. In Phase I of the project, our effort will be concentrated on the development of a prototype CMOS readout module that can be used as the substrate for depositing the Hgl2 films onto, and to show feasibility of the design and film deposition concepts. In Phase II we will optimize the design of the CMOS readout chip for full optimization for the application, increase the overall active area of the chip, and optimize the Hgl2 deposition as required. The final x-ray imager will be constructed in Phase II by tiling eight individual detector modules for a total area of about 100 mm by 100 mm. In Phase II, we will develop a gantry to support the x-ray detector, the micro focus x-ray tube and the specimen. We will provide a mechanism for the rotation of the specimen under computer control (detector and x-ray tube will be stationary). Also, we will develop software for reconstruction of the data in order to obtain the highest quality tomographic images. The prototype system will be tested with phantoms at Photon Imaging, Inc. and with real tissue samples at UCLA.
描述(由申请人提供):
该提案的目标是开发专用的高分辨率计算机断层扫描(CT)设备,用于在外科乳腺活检和外科保乳治疗期间检查切除标本。病变边缘相对于标本边缘的定位,以及估计可能超出标本边缘的病变的方向和范围在外科手术过程中至关重要。标本的放射学检查需要在几分钟内非常快速地进行,以便为外科医生提供所需的反馈,并最大限度地缩短手术时间。
在美国和世界范围内,对切除标本进行放射学检查以帮助手术是常见的做法。然而,这些程序中使用的设备并未针对此任务进行优化。目前使用的设备缺乏所需的对比度,并且不具有足够高的空间分辨率以基于物理密度和有效原子序数充分区分组织。出于这些原因,我们提出了一种新的方法,它结合了一个新的,高分辨率的数字成像检测器的基础上HG12多晶X射线转换器耦合到硅CMOS读出电路和使用的计算机断层成像技术,进一步增强图像的对比度的发展。在项目的第一阶段,我们的努力将集中在开发一个原型CMOS读出模块,可用作沉积Hgl 2薄膜的基板,并显示设计和薄膜沉积概念的可行性。在第二阶段,我们将优化CMOS读出芯片的设计,以实现应用的全面优化,增加芯片的总有源面积,并根据需要优化Hgl 2沉积。最后的X射线成像仪将在第二阶段建造的平铺八个单独的探测器模块的总面积约为100毫米的100毫米。在第二阶段,我们将开发一个机架,以支持X射线探测器,微焦点X射线管和标本。我们将提供一个在计算机控制下旋转样本的机制(探测器和X射线管将是固定的)。此外,我们还将开发用于重建数据的软件,以获得最高质量的断层图像。原型系统将在Photon Imaging,Inc.使用体模进行测试。和加州大学洛杉矶分校的真实的组织样本。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jan S Iwanczyk其他文献
Jan S Iwanczyk的其他文献
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{{ truncateString('Jan S Iwanczyk', 18)}}的其他基金
Hybrid pulse processor for synchrotron detectors
用于同步加速器探测器的混合脉冲处理器
- 批准号:
6586954 - 财政年份:2003
- 资助金额:
$ 10万 - 项目类别:
DIGITAL X-RAY IMAGERS BASED ON HGI2 POLYCRYSTALLINE FILM
基于 HGI2 多晶胶片的数字 X 射线成像仪
- 批准号:
6211543 - 财政年份:2000
- 资助金额:
$ 10万 - 项目类别:
Digital x-ray imaged based on Hgl2 polycrystalline films
基于 Hgl2 多晶薄膜的数字 X 射线成像
- 批准号:
6445813 - 财政年份:2000
- 资助金额:
$ 10万 - 项目类别:
Digital x-ray imaged based on Hgl2 polycrystalline films
基于 Hgl2 多晶薄膜的数字 X 射线成像
- 批准号:
6525970 - 财政年份:2000
- 资助金额:
$ 10万 - 项目类别:
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6180740 - 财政年份:1998
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6015316 - 财政年份:1998
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2649446 - 财政年份:1998
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DEVELOPMENT OF MERCURIC IODIDE ARRAYS FOR SYNCHROTRON RA
SYNCHROTRON RA 碘化汞阵列的开发
- 批准号:
3292272 - 财政年份:1989
- 资助金额:
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DEVELOPMENT OF HGI2 ARRAYS FOR SYNCHROTRON RADIATION
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- 批准号:
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