Gene Expression in Inflammatory Myopathies

描述（由申请人提供）：炎症性肌病基因表达的目标是：(1)通过使用DNA微阵列来表征患有不同亚型炎症性肌病的成年患者的肌肉基因表达模式，并将这些模式与临床表型相关联，(2)提出与炎症性肌病发病机制相关的假设。高密度寡核苷酸微阵列将用于检测炎症性肌病患者肌肉活检标本中的基因表达。这些患者的表型将被很好地描述，并为本提案的临床研究者所知。基因表达谱的数据分析将与临床数据联系起来，以完善疾病分类，并了解炎症性肌病主要亚型之间和内部的区别。差异基因表达的分析也将为这些疾病的发病机制提供线索。这项工作可能为这些疾病提供进一步的诊断方法，并有助于了解其发病机制。

DESCRIPTION (provided by applicant): The goals of Gene Expression in Inflammatory Myopathies are: (1) to characterize patterns of muscle gene expression through the use of DNA microarrays among adult patients with distinct subtypes of inflammatory myopathies and correlate these patterns with clinical phenotypes, and (2) to formulate hypotheses relevant to the pathogenesis of the inflammatory myopathies. High-density oligonucleotide microarrays will be used to assay gene expression in muscle biopsy specimens from patients with inflammatory myopathies. These patients will be phenotypically well described and known to the clinical investigators of this proposal. Data analysis of gene expression profiles will be linked to clinical data to refine disease classification and understand distinctions among and within the major subtypes of inflammatory myopathy. Analysis of differential gene expression will also provide clues to pathogenesis of these disorders. This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis.