Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
基本信息
- 批准号:6620747
- 负责人:
- 金额:$ 18.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-02-01 至 2007-01-31
- 项目状态:已结题
- 来源:
- 关键词:Manduca age difference arthropod genetics chemical kinetics chemical structure function diacylglycerols enzyme model enzyme substrate complex hormone regulation /control mechanism intermolecular interaction intracellular transport invertebrate hormone larva lipid metabolism lipid transport macromolecule mature animal model design /development molecular cloning protein kinase A protein purification radiotracer stereochemistry transport proteins triacylglycerol lipase triglycerides
项目摘要
DESCRIPTION: (provided by the applicant): Unlike vertebrates, where the stored
fatty acids are mobilized as free fatty acids, a great number of insects,
mobilizes fatty acids as an-1, 2-diacylglycerol (DG). The mobilization of TG
stores requires the action of a TG-lipase, whose activity is hormonally
regulated. The substrate of the lipase (TG) is found in large intracellular
lipid droplets, which are constituted by a core of TG surrounded by a complex
surface layer of phospholipids and proteins. On the other hand, the TG-lipase
localizes in the cytosol of lipolytically unstimulated fat body cells.
Lipolysis involves the interaction of the lipase with the surface of the lipid
droplet. It is known that activation of lipolysis promotes both an increase of
intracellular calcium concentration and activation of amp-dependent protein
kinase (A-kinase) but the basic mechanisms involved in how
phosphorylation-dephosphorylation reactions modulate the rate of lipolysis is
unknown. Moreover, little is known about the relevance and nature of the
structural and compositional changes that affect the lipid droplet when
lipolysis is hormonally activated. These changes must ultimately affect the
interaction of the lipase with the lipid substrate and the concomitant
activation of lipolysis. DG moves from the lipid droplet to the plasma membrane
by an uncharacterized mechanism. It appears that after the conversion of TG
into DG on the surface of the lipid droplets, DG would be transferred to a
cytosolic carrier, which in turn would target the delivery of DG across the
plasma membrane. The overall goals of this project are to establish the
mechanisms regulating lipolysis by determining the factors that promotes the
interaction between TG-lipase and its substrate, the lipid droplet and to
define the mechanism of intracellular transport of DG. Clearly the elucidation
of these mechanisms is of fundamental importance in insect biochemistry and
physiology. These studies will provide comprehensive information on the
lipolytic process in insects and this knowledge could also contribute to the
broad field of lipid metabolism and transport in vertebrates.
说明:(由申请人提供):不像脊椎动物,在哪里储存
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Estela L. Arrese其他文献
Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in <em>Manduca sexta</em> fat body
- DOI:
10.1016/s0022-2275(20)32460-3 - 发表时间:
1999-03-01 - 期刊:
- 影响因子:
- 作者:
Estela L. Arrese;Matthew T. Flowers;Justin L. Gazard;Michael A. Wells - 通讯作者:
Michael A. Wells
Estela L. Arrese的其他文献
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{{ truncateString('Estela L. Arrese', 18)}}的其他基金
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
7928353 - 财政年份:2009
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
9133397 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
7012832 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
6421463 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
8204455 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
6849339 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
9306148 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
7990442 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
7657019 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
Mobilization of Triacylglycerol Stores in Insects
昆虫体内三酰甘油储存的动员
- 批准号:
6699052 - 财政年份:2002
- 资助金额:
$ 18.61万 - 项目类别:
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