Percutaneous Respiratory Assist Catheter

经皮呼吸辅助导管

• 批准号: 6698945
• 负责人: William J. Federspiel
• 金额: $ 0.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6698945
• 关键词: aortic balloon pump; biomaterial compatibility; biomedical equipment development; blood oxygenator; carbon dioxide; catheterization; computer simulation; cow; electron microscopy; hemodynamics; hemolysis; hollow fiber separation technique; hypercapnia; implant; nonhuman therapy evaluation; postmortem; respirators; respiratory disease /disorder therapy; respiratory therapy; transposon /insertion element

The objective of this proposal is to develop a percutaneous respiratory assist catheter (PRAC) that can be inserted into the venous system to provide supplemental breathing support, independent of the lungs, for patients requiring short- term (less than 1-2 weeks) respiratory assistance. The PRAC will be designed for percutaneous insertion into a peripheral vein and placement in the central venous system, where it will be exposed to all the blood returning to the heart. The PRAC will incorporate a cylindrical bundle of microporous hollow fiber membranes woven as a fabric that is wrapped around a balloon. The balloon is pulsed with helium and enhances gas exchange by pumping blood past the hollow fibers at velocities much greater than would otherwise exist in the vena cava. The specific aims of the project are to: 1. Fabricate candidate PRAC devices with insertional diameters of 25-28 Fr (8-9 mm) and evaluate the functional mass transfer characteristics in an in-vitro test loop. We will establish how the gas exchange performance of the PRAC depends on key operating and design parameters. 2. Evaluate and optimize balloon pulsation in the PRAC to improve gas exchange. We will principally explore changes in balloon geometry and balloon pulsation mode, and we will use flow visualization, local gas tension measurements, and computational simulations to help guide our design development. 3. Perform acute calf implants of the PRAC to assess the gas exchange functionality in-situ and any adverse anatomical, physiological and biocompatibility effects associated with short- term implantation. We will also evaluate the hemolysis potential of candidate PRAC designs in-vitro using bovine blood in a bench flow loop. Our target is a percutaneous assist catheter that can provide 75- 85 ml/min of extrapulmonary CO2 removal at normocapnia and that could be used as an adjuvant or replacement to existing therapy for patients with acute lung failure (ARDS, pneumonia) or acute on chronic lung failure (COPD with exacerbation).

该提案的目标是开发一种经皮呼吸辅助导管（PRAC），可插入静脉系统，为需要短期（少于1-2周）呼吸辅助的患者提供独立于肺部的补充呼吸支持。 PRAC 将设计用于经皮插入外周静脉并放置在中央静脉系统中，在那里它将暴露于所有返回心脏的血液。 PRAC 将采用一束圆柱形微孔中空纤维膜，编织成织物，包裹在气球周围。气球用氦气进行脉冲，并通过将血液以比腔静脉中存在的速度大得多的速度泵过中空纤维来增强气体交换。 该项目的具体目标是： 1. 制造插入直径为 25-28 Fr（8-9 毫米）的候选 PRAC 装置，并评估体外测试回路中的功能传质特性。 我们将确定 PRAC 的气体交换性能如何取决于关键操作和设计参数。 2. 评估和优化 PRAC 中的球囊脉动，以改善气体交换。 我们将主要探索气球几何形状和气球脉动模式的变化，并且我们将使用流动可视化、局部气体张力测量和计算模拟来帮助指导我们的设计开发。 3. 进行 PRAC 的急性小腿植入，以评估原位气体交换功能以及与短期植入相关的任何不利的解剖学、生理学和生物相容性影响。 我们还将在工作台流动回路中使用牛血来评估候选 PRAC 设计的溶血潜力。我们的目标是一种经皮辅助导管，它可以在正常碳酸血症下提供 75-85 毫升/分钟的肺外二氧化碳清除量，并且可以用作急性肺衰竭（ARDS、肺炎）或慢性肺衰竭急性发作（COPD 加重）患者现有疗法的辅助或替代疗法。