Phytoestrogens and breast cancer risk

描述（由申请人提供）：拟议的职业发展奖 将帮助Susan McCami博士在专注于 慢性病的营养流行病学，结合她的背景， 营养科学和流行病学，并获得新的专业知识， 流行病学 她的近期目标如下所述，包括调查 食物成分与荷尔蒙活动之间的关系 （植物雌激素）和乳腺癌风险的回顾性和实验性研究 设计，并与社会部正在进行的研究合作， 预防医学（SPM） SPM在饮食研究方面有着悠久的历史， 癌症，非常适合这项研究。 此外，她还将获得 培训和洞察实验室方法的整合， 流行病学和将遗传易感性纳入流行病学 研究，并在肿瘤学，分子流行病学， 内分泌学 这里提出了两项研究，检查膳食植物雌激素在 绝经前和绝经后乳腺癌的病因。 第一个利用 数据来自一项大型病例对照研究，目前正在收集数据。 2001年春季结束）。 分析将探讨仪式之间的关系， 膳食中木脂素（主要植物雌激素来源）的摄入量对乳腺癌风险的影响。 将利用来自对照的数据来检查 膳食木酚素摄入量和其他膳食，非膳食，和生物标志物， 营养和慢性病风险因素。 最后，我们将研究遗传 通过估计风险，将易感性作为这些关系的修正因子 按雌激素代谢相关基因多态性分层， 和COMT。 第二项研究涉及收集新的数据， 膳食中添加木脂素对血清雌激素和植物雌激素影响 水平，以及CYP 17和COMT多态性对这种关系的影响。 研究中的受试者将食用亚麻籽补充剂七天， 基线和补充后血清雌激素和 评估植物雌激素水平。 这些调查，结合回顾性 实验设计和遗传分析将有助于阐明 饮食中植物雌激素摄入在激素病因学中的作用- 敏感性癌症

DESCRIPTION (provided by applicant): The proposed Career Development Award will help Dr. Susan McCami gain independence in a career focused on the nutritional epidemiology of chronic disease, integrating her background in nutritional sciences and epidemiology, and gaining new expertise in molecular epidemiology. Her immediate goals as outlined below include an investigation of tho relationship between food components with hormonal activities (phytoestrogens) and breast cancer risk using retrospective and experimental designs and to collaborate with ongoing research in the Department of Social and Preventive Medicine (SPM). SPM has a long history of research in diet and cancer and is ideally suited for this research. In addition, she will receive training and insight into the integration of laboratory methods into epidemiology and the inclusion of genetic susceptibility in epidemiologic studies, and further training in onclogy, molecular epidemiology, and endocrinology. Proposed here are two studies examining the role of dietary phytoestrogens in the etiology of pre- and postmenopausal breast cancer. The first utilizes data from a large case-control study for which data collection is currently ongoing (ending Spring 2001). Analyses will examine rite relationship between dietary intakes of lignans (major phytoestrogen source) on breast cancer risk. Data from the controls will be utilized to examine the relationship between dietary lignan intake and other dietary, non-dietary, and biomarkers of nutrition and chronic disease risk factors. Finally, we will examine genetic susceptibility as a modifying factor on these relationships by estimating risk stratified by polymorphisms of genes related to estrogen metabolism, CYP 17 and COMT. The second study involves collection of new data investigating the effect of dietary lignan supplementation on serum estrogen and phytoestrogen levels, and the impact of CYP17 and COMT polymorphisms on this relationship. Subjects in the study will consume flaxseed supplements for seven days and differences between baseline and postsupplementation serum estrogen and phytoestrogen levels assessed. These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer.