Phytoestrogens and breast cancer risk

简介(由申请人提供)：建议的职业发展奖 将帮助苏珊·麦卡米博士在专注于 慢性疾病的营养流行病学，结合她在 营养科学和流行病学，并获得分子方面的新专业知识 流行病学。如下所述，她的近期目标包括调查 食物成分与荷尔蒙活动的关系 (植物雌激素)和乳腺癌风险的回顾和实验研究 设计并与社会部正在进行的研究合作 和预防医学(SPM)。SPM在饮食和营养方面有着悠久的研究历史 癌症，是这项研究的理想选择。此外，她还将收到 培训和洞察实验室方法与 流行病学与流行病学中的遗传易感性 研究和进一步培训肿瘤学、分子流行病学和 内分泌学。 这里提出了两项研究，考察饮食中植物雌激素在 绝经前和绝经后乳腺癌的病因。第一个利用 来自一项大型病例对照研究的数据，目前正在收集数据 正在进行中(2001年春季结束)。分析将检查礼仪之间的关系 饮食摄入木脂素(主要的植物雌激素来源)对乳腺癌风险的影响。 来自控件的数据将被用来检查 膳食木脂素摄入量和其他膳食、非膳食和生物标志物 营养和慢性病危险因素。最后，我们将检查基因 通过估计风险，将易感性作为这些关系的修正因素 根据雌激素代谢相关基因的多态性分层，CyP17 和COMT。第二项研究涉及收集新的数据，调查 日粮中补充木脂素对血清雌激素和植物雌激素的影响 水平，以及CYP17和COMT基因多态对这种关系的影响。 研究中的受试者将连续七天服用亚麻籽补充剂，并 补充前和补充后血清雌激素水平的差异 植物雌激素水平评估。这些调查，结合了回顾 实验设计以及基因分析将有助于阐明 饮食中的植物雌激素摄入在一种激素的病因学中的作用- 敏感型癌症。

DESCRIPTION (provided by applicant): The proposed Career Development Award will help Dr. Susan McCami gain independence in a career focused on the nutritional epidemiology of chronic disease, integrating her background in nutritional sciences and epidemiology, and gaining new expertise in molecular epidemiology. Her immediate goals as outlined below include an investigation of tho relationship between food components with hormonal activities (phytoestrogens) and breast cancer risk using retrospective and experimental designs and to collaborate with ongoing research in the Department of Social and Preventive Medicine (SPM). SPM has a long history of research in diet and cancer and is ideally suited for this research. In addition, she will receive training and insight into the integration of laboratory methods into epidemiology and the inclusion of genetic susceptibility in epidemiologic studies, and further training in onclogy, molecular epidemiology, and endocrinology. Proposed here are two studies examining the role of dietary phytoestrogens in the etiology of pre- and postmenopausal breast cancer. The first utilizes data from a large case-control study for which data collection is currently ongoing (ending Spring 2001). Analyses will examine rite relationship between dietary intakes of lignans (major phytoestrogen source) on breast cancer risk. Data from the controls will be utilized to examine the relationship between dietary lignan intake and other dietary, non-dietary, and biomarkers of nutrition and chronic disease risk factors. Finally, we will examine genetic susceptibility as a modifying factor on these relationships by estimating risk stratified by polymorphisms of genes related to estrogen metabolism, CYP 17 and COMT. The second study involves collection of new data investigating the effect of dietary lignan supplementation on serum estrogen and phytoestrogen levels, and the impact of CYP17 and COMT polymorphisms on this relationship. Subjects in the study will consume flaxseed supplements for seven days and differences between baseline and postsupplementation serum estrogen and phytoestrogen levels assessed. These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer.