Phytoestrogens and breast cancer risk

植物雌激素和乳腺癌风险

• 批准号: 6747529
• 负责人: Susan E McCann
• 金额: $ 7.77万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6747529
• 关键词: alcoholic beverage consumption; breast neoplasms; cancer risk; clinical research; dietary supplements; disease /disorder etiology; estrogens; estrone; female; genetic polymorphism; genetic susceptibility; hormone related neoplasm /cancer; human subject; lactones; lignans; neoplasm /cancer epidemiology; nutrition related tag; phytoestrogens; postmenopause; seeds; smoking; steroid 17alpha monooxygenase; steroid hormone metabolism; tobacco abuse; women's health

DESCRIPTION (provided by applicant): The proposed Career Development Award will help Dr. Susan McCami gain independence in a career focused on the nutritional epidemiology of chronic disease, integrating her background in nutritional sciences and epidemiology, and gaining new expertise in molecular epidemiology. Her immediate goals as outlined below include an investigation of tho relationship between food components with hormonal activities (phytoestrogens) and breast cancer risk using retrospective and experimental designs and to collaborate with ongoing research in the Department of Social and Preventive Medicine (SPM). SPM has a long history of research in diet and cancer and is ideally suited for this research. In addition, she will receive training and insight into the integration of laboratory methods into epidemiology and the inclusion of genetic susceptibility in epidemiologic studies, and further training in onclogy, molecular epidemiology, and endocrinology. Proposed here are two studies examining the role of dietary phytoestrogens in the etiology of pre- and postmenopausal breast cancer. The first utilizes data from a large case-control study for which data collection is currently ongoing (ending Spring 2001). Analyses will examine rite relationship between dietary intakes of lignans (major phytoestrogen source) on breast cancer risk. Data from the controls will be utilized to examine the relationship between dietary lignan intake and other dietary, non-dietary, and biomarkers of nutrition and chronic disease risk factors. Finally, we will examine genetic susceptibility as a modifying factor on these relationships by estimating risk stratified by polymorphisms of genes related to estrogen metabolism, CYP 17 and COMT. The second study involves collection of new data investigating the effect of dietary lignan supplementation on serum estrogen and phytoestrogen levels, and the impact of CYP17 and COMT polymorphisms on this relationship. Subjects in the study will consume flaxseed supplements for seven days and differences between baseline and postsupplementation serum estrogen and phytoestrogen levels assessed. These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer.

描述（由申请人提供）：拟议的职业发展奖 将帮助 Susan McCami 博士在专注于以下领域的职业中获得独立 慢性病的营养流行病学，整合她的背景 营养科学和流行病学，并获得分子方面的新专业知识 流行病学。 她的近期目标如下所述，包括进行调查 食物成分与激素活性之间的关系 （植物雌激素）和乳腺癌风险的回顾性和实验性研究 设计并与社会系正在进行的研究合作 和预防医学（SPM）。 SPM在饮食和饮食方面有着悠久的研究历史 癌症，非常适合这项研究。 此外，她还将获得 对实验室方法整合的培训和见解 流行病学以及将遗传易感性纳入流行病学 肿瘤学、分子流行病学等方面的研究和进一步培训 内分泌学。 这里提出了两项​​研究，探讨膳食植物雌激素在 绝经前和绝经后乳腺癌的病因学。 第一个利用的是 数据来自一项大型病例对照研究，目前正在收集数据 正在进行中（2001 年春季结束）。 分析将检查仪式之间的关系 膳食中木脂素（主要植物雌激素来源）的摄入量对乳腺癌风险的影响。 来自控件的数据将用于检查之间的关系 膳食木脂素摄入量和其他膳食、非膳食和生物标志物 营养和慢性病危险因素。 最后，我们将检查遗传 通过估计风险将敏感性作为这些关系的修改因素 根据雌激素代谢相关基因 CYP 17 的多态性进行分层 和COMT。 第二项研究涉及收集新数据调查 膳食补充木酚素对血清雌激素和植物雌激素的影响 水平，以及 CYP17 和 COMT 多态性对此关系的影响。 研究对象将食用亚麻籽补充剂 7 天， 基线和补充后血清雌激素之间的差异 评估植物雌激素水平。 这些调查结合回顾性 实验设计以及遗传分析将有助于阐明 膳食植物雌激素摄入量在激素病因学中的作用 敏感癌症。